神经生长因子在神经病理性疼痛中的作用机制以及相关药物治疗的研究进展

马 鸿倩, 蒋 维
大连医科大学

摘要

神经营养蛋白家族中的神经生长因子（nerve growth factor,NGF）是一种周围性疼痛介质，在炎症性疼痛状态下 NGF 被上调，并通过外周敏化、中枢敏化、参与炎症反应等机制在神经病理性疼痛中发挥着重要的作用，而 NGF 抗体及其受体抗体在许多疼痛模型中是有效的镇痛药。本文将就 NGF 在神经病理性疼痛中发挥的作用及相关药物治疗作一综述。

关键词

神经生长因子；神经病理性疼痛

参考

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