首页出版说明中文期刊中文图书环宇英文官网付款页面

蜂王浆醇提物对酒精诱导肝损伤小鼠的保护作用

尚 曼, 张 良才, 修 贺明
石家庄科技创业投资有限公司

摘要


探讨蜂王浆乙醇提取物（简称：蜂王浆醇提物，功效成分：10-羟基-2-癸烯酸，简写：10-HDA）对酒精诱导的小鼠肝损伤的保护作用。试验动物随机分成5组，每组10只，分别为阴性对照组、模型对照组、模型蜂王浆醇提物低剂量干预组、模型蜂王浆醇提物高剂量干预组、正常鼠蜂王浆醇提物高剂量干预组。对实验小鼠进行灌胃，试验结束后测定小鼠的肝组织中的TG、GSH、MDA等指标。结果表明，蜂王浆乙醇提取物对酒精诱导的小鼠化学性肝损伤具有保护作用。

关键词


蜂王浆醇提物；酒精；肝损伤；小鼠；

全文:

PDF


参考


[1] 中华人民共和国国家标准 GB9697-2008，蜂王浆 [2] 陈亚玲，张晶.蜂王浆的研究进展[J]食品研究与开发.2015,36(1):148 [3] J Wang, W Zhang, H Zou, et al. 10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K–AKT pathway[J]. International Immunopharmacology, 2015, 28: 97－104. [4] Astrid Spannhoffl, Yong KeeKiml, Noel J, et al. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees[J]. EMBO reports, 2011, 12(3). [5] 徐小冬，俞利平，尹洪萍. 慢性酒精性肝损伤小鼠COX-2、TNF-α 的表达及蜂王浆的干预作用[J]. Healthy Research, 20ll, 31(1)：4－8. [6] 赵瑞林. E-10-羟基-2-癸烯酸在制备肝脏疾病的药品或保健品的应用：中国，104825435 A[P]. 2015-08-12. [7] 赵瑞林. E-10-羟基-2-癸烯酸在防治化学肝损伤的药物或保健品中的应用：中国，104622861 A [P]. 2015-05-20. [8] 茹清静，施维群，李天等. 10-羧基-2-癸烯酸及蜂王浆防治小鼠肝纤维化的实验研究[J]. 中西医结合肝病杂志, 2010, 20 (3). [9] 凌树森，周慧萍，唐春萍等. 10-羟基癸烯酸在动物体内吸收、分布、代谢和排泄[J]. 药学学报, 1988, 23 (1) : 1－7. [10] Astrid Spannhoff, Yong KeeKim, Noel J.-M. Raynal， et al. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees[J]. EMBO reports, 2011,12(3): 238－243. [11] F. Blanchard, C. Chipoy, Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases[J]. Drug Discov. Today, 2005,10: 197－204. [12] A.M. Grabiec, S. Krausz,W. de Jager, T. Burakowski, D. Groot, M.E. Sanders, et al. Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue[J]. J. Immunol, 2010, 184: 2718－2728. [13 ] L.C. Huber, J. Stanczyk, A. Jungel, S. Gay, Epigenetics in inflammatory rheumatic diseases[J]. Arthritis Rheum, 2007, 56: 3523－3531. [14 ] M.D. Shahbazian, M. Grunstein, Functions of site-specific histone acetylation and deacetylation[J]. Annu. Rev. Biochem , 2007, 76: 75－100. [15] J. Gillespie, S. Savic, C. Wong, A. Hempshall, M. Inman, P. Emery, et al., Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients[J]. Arthritis Rheum , 2012, 64: 418－422. [16] Kohlmeier L: Biomarkers of fatty acids exposure and breast cancer risk[J]. Am J Clin Nutr ,1997, 66(6 Suppl):1548S－1556S. [17] Vucevic D, Melliou E, Vasilijic S, Gasic S, Ivanovski P, Chinou I, Colic M: Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro[J]. Int Immunopharmacol, 2007, 7:1211－1220.




DOI: http://dx.doi.org/10.18686/yxyj.v1i7.13479

Refbacks

  • 当前没有refback。