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Journal | [J] 世界医学前沿 Volume 4, Issue 7. 2022.
代谢综合征与腰椎间盘退变及其炎症因子的研究进展
作者 : 白 天一, 刘 正蓬, 张 义龙, 张 书熠, 冯 超
DOI: 10.12361/2705-1161-04-07-118283
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摘要 / Abstract
腰椎间盘退变相关疾病（腰椎管狭窄症、退行性椎体滑移、椎间盘突出症）是腰痛的主要原因， 临床发病率高，探索椎间盘退变的影响因素有较大的临床意义。退行性椎间盘中炎症因子 IL-1β 和 TNF-α 水平升高是腰椎间盘退变的关键因素，研究发现代谢性疾病与椎间盘的退变有显著的联系，其中肥胖、糖尿病 等代谢性疾病与胸椎椎间盘退变有较强的相关性，同时具有一个或多个代谢性疾病的患者更容易发生椎间盘退 变，代谢综合征可能是引起退行性椎间盘炎症因子升高的始动因素，本文综述了代谢综合征与腰椎间盘退变及 其炎症因子的相关性，为腰椎间盘退变性疾病的预防和治疗提供新思路。
关键词 / Keywords
腰椎间盘退变；炎症因子；代谢综合征
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  • [1] Stubbs B, Koyanagi A, Thompson T, et al.
  • The epidemiology of back pain and its relational with
  • depression, psychosis, anxiety, sleep disturbances, and
  • stress sensitivity: data from 43 low-and middle-income
  • countries[J]. Gen Hosp Psychiatry,2016, 43: 63-70
  • [2] Arnbak B, Jensen TS, Egund N, et al. Prevalence
  • of degenerative and spondyloarthritis-related magnetic
  • resonance imaging findings in the spine and sacroiliac joints
  • in patients with persistent low back pain[J]. Eur Radiol,
  • 2016,26(4):1191-203
  • [3] Deborah J. Gorth, Irving M. Shapiro, Makarand V.
  • RisbudDisc-overy of the Driversof Inflammation Induced
  • Chronic Low Back Pain: From Bacteria to Diabetes[J].
  • Discov Med,2015 ,20(110): 177–184
  • [4] J.G. Burke, R.W. Watson, D. McCormack, et al ,
  • Intervertebral discs which cause low back pain secrete high
  • levels of proinflammatory mediators[J]. Bone Joint Surg.
  • Br,2002,84 (2):196–201
  • [5] 孙中仪 , 田纪伟 . 炎性因子与椎间盘退变的研
  • 究进展 . 中华医学杂志 . 2013. 93(41): 3322-3324
  • [6] 赵赫 , 俞兴 , 唐向盛等 . 炎性因子 IL-1β、
  • TNF-α 与椎间盘退变关系的研究进展 . 中国骨伤 .
  • 2017.30(9): 866-871
  • [7] Cui LY, Liu SL, Ding Y, et al. IL-1beta sensitizes
  • rat intervertebral disc cells to Fas ligand mediated apoptosis
  • in vitro. Acta Pharmacol Sin. 2007. 28(10): 1671-6
  • [8] Binch AL，Cole AA，Breakwell LM，et al.
  • Expression and regulation of neurotrophic and angiogenic
  • factors during human intervertebral disc degeneration[J].
  • Arthritis Res Ther,2014,16(5):416
  • [9] Ｇ ruber HE，Hoelscher Ｇ L，Ingram JA，et al.
  • Increased IL 17 expression in degenerated human discs and
  • increased production in cultured annulus cells exposed to
  • IL 1β and T Ｎ F α[J]. Biotech Histochem，2013,88（6）：
  • 302-310
  • [10] Pattappa Ｇ，Peroglio M，Sakai D，et al. CC
  • L5/RA Ｎ TES is a key chemoattractant released by deg
  • enerative intervertebral discs in organ culture[J]. Eur Cell
  • Mater,2014,27:124-136
  • [11] Wang X，Ｗ ang H，Ｙ ang H，et al. Tumor
  • necrosis factor α and interleukin 1β dependent matrix
  • metalloproteinase 3 expression in nucleus pulposus cells re
  • ｑ uires cooperative signalingvia syndecan 4 and mitogen
  • activated protein kinase Ｎ FκB axis：implications in
  • inflammatory disc disease[J]. Am J Pathol，2014,184 (9):25
  • 60-2572
  • [12]Locksley RM, Ｋ illeen Ｎ，Lenardo MJ. The T
  • Ｎ F and T Ｎ F receptor superfamilies：integrating mamm
  • alian biology [J]. Cell，2001,104(4):487 － 501
  • [13]Huang TT, Kudo N, Yoshida M, Miyamoto
  • S. A nuclear export signal in the N-terminal regulatory
  • domain of IkappaBalpha controls cytoplasmic localization
  • of inactive NF-kappaB/IkappaBalpha complexes. Proc
  • Natl Acad Sci U S A. 2000. 97(3): 1014-9
  • [14]Aoki Y, An HS, Takahashi K, et al. Axonal
  • growth potential of lumbar dorsal root ganglion neurons in
  • an organ culture system: response of nerve growth factorsensitive neurons to neuronal injury and an inflammatory
  • cytokine. Spine 2007;32:857–63
  • [15] 中国 2 型糖尿病防治指南 (2017 年版 )[J]. 中
  • 国实用内科杂志 ,2018,38(04):292344
  • [16]Swaroop JJ, Rajarajeswari D, NaiduJN.
  • Association of TNF-α with insulin resistance in type 2
  • diabetes mellitus[J]. Indian J Med Res, 2012, 135: 127-130
  • [17] 陈晨 , 朱千里 , 叶渤之 , 等 . 高血压合并糖尿
  • 病前期炎症因子 TNF-α 和 IL-6 水平的研究 [J]. 心电
  • 与循环 , 2016, 35(3): 170-180
  • [18]Kentish SJ, O'Donnell TA, Isaacs NJ, et al.
  • Gastricvagal afferent modulation by leptin is influenced by
  • food intake status[J]. J Physiol, 2013, 591(7): 1921-1934
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