Objective:To analyze the clinical adverse reactions of the combined application of a variety of western medicines,and put forward relevant countermeasures.Methods:A total of 120 patients treated with combined western medicine in our hospital from February 2022 to February 2023 were selected for analysis. They were divided into study group and reference group respectively,after analyzing clinical adverse reactions,relevant countermeasures were adopted.No intervention measures were taken.Watch for adverse reactions.Results:The causes of adverse reactions in the two groups mainly included:poor compatibility,repeated medication,improper usage,improper dosage,etc.The occurrence frequency and incidence of adverse reactions in the study group were lower than those in the reference group,and the difference was statistically significant(P<0.05).Conclusion:The combined use of a variety of western drugs is easy to lead to the occurrence of clinical adverse reactions.Detailed analysis of related factors can improve the rationality of drug use,effectively reduce the occurrence of adverse reactions,and play a positive role in improving drug safety.