OBJECTIVE: To observe the effectiveness of different methods in the treatment of severe asthma. METHODS: Ninety patients admitted from 2020.2 to 2022.8 were divided into groups A and B, 45 patients each, and all were given basic symptomatic treatment, group A was given nebulized inhalation of budesonide suspension, group B was mechanically ventilated on the basis of group A's protocol, and the treatment was compared between groups. Results: After 3 weeks of continuous treatment, the lung function (FEV1, PEF, FEV1/FVC) levels of patients in group B were higher than those in group A, and the difference reached a significant level (P < 0.05). The incidence of adverse reactions in groups A and B was 8.89% and 6.67% respectively, which was not statistically significant (P > 0.05). Conclusion: In patients with severe asthma, early mechanical ventilation with inhalation of budesonide suspension can improve lung function more rapidly and with higher safety, and is worth promoting.