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Journal | [J] 预防医学研究 Volume 5, Issue 8. 2023.
环状RNA在甲状腺癌中的研究进展
作者 : 姜 泰先, 刘 阁玲
DOI: 10.12361/2705-0459-05-08-142818
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摘要 / Abstract
甲状腺癌(thyroidcancer,TC)已成为最常见内分泌肿瘤,是近年来发病率最快的肿瘤,TC的存活率高于大多数其他类型的癌症,但它取决于许多因素,包括TC的具体类型和疾病的分期｡环状RNA(circRNA)是一类新型的长链非编码RNA,具有闭环结构,在控制TC发生的复杂基因调控网络中发挥着重要作用｡circRNA最重要的功能是特异性结合microRNAs的能力｡circRNA可以通过调节细胞周期以及影响细胞代谢等不同的途径调节TC侵袭和进展｡根据circRNA的特征,它们被确定为诊断肿瘤的潜在生物标志物｡本文就circRNA的功能､意义及其在TC发病中的潜在临床意义进行综述｡
关键词 / Keywords
环状RNA､甲状腺癌､ceRNAs调控网络
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