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Journal | [J] 临床医学研究 Volume 5, Issue 11. 2023.
中药治疗非酒精性脂肪性肝炎肝纤维化的作用机制
作者 : 杜 田田, 安 纪红
DOI: 10.12361/2705-0939-05-11-147731
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摘要 / Abstract
目的：非酒精性脂肪性肝病（NAFLD）是全球最普遍的肝病，影响 20-25% 的成年人口。在 25% 的患者中，NAFLD 进 展为非酒精性脂肪性肝炎（NASH），这增加了肝硬化，肝衰竭和肝细胞癌发展的风险。在 NASH 患者中，肝纤维化是死亡率 的主要决定因素。早期的肝纤维化经过规范有效的抗肝纤治疗后可以逆转，若不及时给予干预，肝纤维化的程度将逐渐加 重并进展为肝硬化，最终发展为肝细胞癌。因此，积极防治肝纤维化具有重要意义。然而目前西医对于肝纤维化的治疗比 较单一、局限，缺乏疗效确切且公认的抗纤维化药物，现有的治疗手段无法满足医疗需求。随着国内外学者的研究深入， 中草药成为了逆转肝纤维化和抗纤维化进展的热点，并发现了多层次、多靶点、多途径的优势。
关键词 / Keywords
非酒精性脂肪性肝炎；肝纤维化；中药；作用机制
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