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Journal | [J] 医学研究 Volume 6, Issue 7. 2024.
Metrnl与人类疾病关系的研究进展
作者 : 宋丹 丹1, 宋志 慧1, 柴金 杰1, 蔡苗 苗1, 姚春 凤3
DOI: 10.12361/2661-3603-06-07-160831
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摘要 / Abstract
摘要：Metrnl(Meteorin-like)是一种新型的脂肪细胞因子，是神经营养调节因子(Meteorin)的同源蛋白。其生物学功能包括：一、促进脂肪褐色化及能量消耗；二、调节机体免疫；三、调节脂肪细胞增殖、分化；四、调节骨生成。这些生物学功能在人类疾病中发挥重要作用。本文就Metrnl与人类疾病的研究进展予以综述，得出结论，在人类疾病中，Metrnl参与呼吸系统、消化系统、内分泌系统及免疫系统等多种疾病的发生发展，但Metrnl在人体中的功能有待进一步验证，还需要做大量的工作来研究Metrnl的结构－功能关系及其在相关疾病中的调控机制，以开发其作为新的治疗靶点。
关键词 / Keywords
关键词：Metrnl蛋白、脂代谢、Ⅱ型糖尿病、冠心病、炎症性疾病Metrnl的概述
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  • [1] JesperRoland,Jørgensen,Anette,Fransson,Lone,Fjord-Larsen,Lachlan H,Thompson,JeffreyP,Houchins,Nuno,Andrade,Malene,Torp,Nisse,Kalkkinen,Elisabet,Andersson,Olle,Lindvall,Mats,Ulfendahl,Søren,Brunak,Teit E,Johansen,Lars U,Wahlberg.Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo.[J].Experimental neurology,2012,233(1):172-81.DOI:10.1016/j.expneurol.2011.09.027.[2] 宫伟雁.METEORIN样分泌性蛋白在骨组织中的表达及其功能研究[D].中国协和医科大学,2007.[3] Zhi-Yong L ,Si-Li Z ,Pei W , et al.Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.[J].CNS neuroscience therapeutics,2014,20(4):344-54.[4] Rao R R ,Long Z J ,White P J , et al.Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis[J]. Cell,2014,157(6): 1279-1291.[5] 黄芳,费俭.神经营养因子[J].中国细胞生物学学报, 1996, 018(001):17-21.DOI:CNKI:SUN:XBZZ.0.1996-01-006.[6] Kanako W ,Yuki A ,Katsuyuki Y , et al.Latent process genes for cell differentiation are common decoders of neurite extension length.[J].Journal of cell science,2012, 125(Pt 9):2198-211.[7] Jinsuke N,KimiyoY,Hiromi H , et al.Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension.[J].The EMBO journal,2004, 23(9):1998-2008.[8] Kiliaan J A ,Arnoldussen C A I ,Gustafson R D .Adipokines: a link between obesity and dementia?[J].The Lancet Neurology,2014,13(9):913-923.[9] Yuhei,Amano,Yudai,Nonaka,Reo,Takeda,Yutaka,Kano,Daisuke,Hoshino.Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats.[J].Physiological reports,2020,8(16):e14540.DOI:10.14814/phy2.14540.[10] 정태우,김형천,방준석等.METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR δ -dependent pathways in skeletal muscle of mice[J].Experimental and Molecular Medicine,2018, 50(S2):1-11.[11] Zheng S L , Wang P , Xu J ,et al.Adipocyte Metrnl Antagonizes Insulin Resistance Through PPAR γSignaling.[J].Diabetes: A Journal of the American Diabetes Association, 2015.[12] J J O .Cytokines: past, present, and future.[J].International journal of hematology,2001,74(1):3-8.[13] Irina,Ushach,Gerardo,Arrevillaga-Boni,Gina N,Heller,Egest,Pone,Marcela,Hernandez-Ruiz,Jovani,Catalan-Dibene,Peter,Hevezi,Albert,Zlotnik.Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation.[J].Journal of immunology (Baltimore, Md. : 1950),2018,201(12):3669-3676.DOI:10.4049/jimmunol.1800435.[14] The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux[J].The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation,2016,126(1):12-22.[15] Hadi,Khodabandehloo,Sattar,Gorgani-Firuzjaee,Ghodratollah,Panahi,Reza,Meshkani.Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction.[J].Translational research : the journal of laboratory and clinical medicine,2016,167(1):228-56.DOI:10.1016/j.trsl.2015.08.011.[16] Sacramento F J ,Andrzejewski K ,Melo F B , et al.Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes[J].International Journal of Molecular Sciences,2020,21(15):[17] Lee H J ,Kang E Y ,Kim M J , et al.Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes[J].Diabetes Research and Clinical Practice,2018,1357-10.[18] Wenchao H ,Rui W ,Bei S .Meteorin-Like Ameliorates β Cell Function by Inhibiting β Cell Apoptosis of and Promoting β Cell Proliferation via Activating the WNT/ β -Catenin Pathway[J].Frontiers in Pharmacology,2021,12627147-627147.[19] D L ,K L ,D R , et al.METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans.[J].International journal of obesity (2005),2017,41(1):112-119.[20] 《中国心血管健康与疾病报告2022》概要[J].中国介入心脏病学杂志,2023,31(07):485-508.[21] Saif A ,Roshan A ,Haseeb A , et al.Role of adipokines (omentin and visfatin) in coronary artery disease[J].Nutrition, Metabolism and Cardiovascular Diseases,2023,33(3):483-493.[22] Zheng S ,Li Z ,Song J , et al.Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis[J].Acta Pharmaceutica Sinica B,2023,13(04):1568-1587.[23] Zheng-Xia L ,Hui-Hong J ,Min-Peng Y , et al.Serum Metrnl is associated with the presence and severity of coronary artery disease.[J].Journal of cellular and molecular medicine,2019,23(1):271-280.[24] Xu L, Cai Y, Wang Y, Xu C. Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells [J]. Med Sci Monit. 2020;26:e924564 H9C2 Cells. Med Sci Monit. 2020 Jun 28;26:e924564. [25] Hu C ,Zhang X ,Song P , et al.Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway[J].Redox Biology,2020,37101747-101747.[26] R M R ,Stefanie K ,H M T , et al.Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.[J].Science (New York, N.Y.),2022,376(6599):1343-1347.[27] Buğra K ,Erol D A ,Ferhan K , et al.Is Metrnl an Adipokine İnvolved in the Anti-inflammatory Response to Acute Exacerbations of COPD?[J].Lung, 2020,198(2):307-314.[28] Gao X , Leung T , Wong W ,et al.Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma[J].中国免疫学杂志:英文版, 2022.[29] Lugen Z ,Sitang G ,Yuanyuan G,et al.The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10-/-Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis.[J].Journal of Crohn's colitis,2019,13(7):931-941.[30] Bridgewood C ,Russell T ,Weedon H , et al.The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts[J].Clinical Immunology,2019,208108253.[31] Jiabao L ,Shuangshuo J ,Yue Y , et al.Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF- κ B and NLRP3/caspase-1/GSDMD signaling[J].Biomedicine Pharmacotherapy,2023,158114118-114118.[32] Woo T J ,Hyeon D P ,Jin T K , et al.Meteorin-like protein (METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ–mediated signaling pathways[J].Advances in Medical Sciences, 2021,66(1):155-161.
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