Objective: to understand the effect of individualized nursing on improving the nursing quality of patients with chronic urticaria. Methods: 100 patients with chronic urticaria in our hospital from May 2016 to July 2018 were randomly divided into two groups. The patients in the routine nursing group were given routine nursing care, and the patients in the personalized nursing group were given personalized nursing during the treatment. The satisfaction of the two groups was compared; the scores of gqli-74 questionnaire and self rating Anxiety Scale before and after nursing, and the score of nursing quality. Results: the satisfaction of individualized nursing group was 100%, which was higher than 80.00% of routine nursing group, X2 = 6.142. Gqli-74 questionnaire score was 93.45 ± 2.84, self rating Anxiety Scale score was 24.21 ± 1.14, which was better than that of routine nursing group (84.44 ± 2.21, 39.21 ± 2.55), T score was 7.634 and 8.312, P < 0.05. The nursing quality score of personalized nursing group was 95.45 ± 2.75, which was higher than that of routine nursing group (81.21 ± 2.01), X2 = 6.213, P < 0.05. Conclusion: the effect of individualized nursing on patients with chronic urticaria during the treatment is accurate, which can improve the quality of nursing service, improve the quality of life and improve the emotional state of patients.