手机版 English 帮助中心
外文文献知网节
文献信息节点
基本信息 摘要 关键词 核心评价 相关文献
Journal | [J] 医学论坛 Volume 3, Issue 10. 2021.
急性缺血性卒中患者静脉溶栓后出血转化的研究现状
作者 : 王 玉青, 李 永秋, 马 佳丽, 李 佳宁, 周 彦君, 李 姗
DOI: 10.18686/yxlt.v3i10.66421
全部来源
获取全文
摘要 / Abstract
在中国，急性缺血性脑卒中（Acute ischemic stroke,AIS）是导致患者致残和致死的首位原因[1]，目前指南推荐重组组织型纤溶酶原激活剂rt-PA是AIS患者在发病后4.5h内血管再通的最有效的治疗手段之一[2]，可以有效改善患者的临床神经功能缺损症状，降低死亡和严重致残的发生率。但静脉溶栓后导致的出血转化，尤其是症状性出血转化sICH，可使患者临床症状加重，造成患者脑组织不可逆损害、不良远期预后及神经功能结局。本文就溶栓后出血转化的类型、发病机制、危险因素及预测模型作一综述，为急性脑梗死患者的临床治疗做出指导。
关键词 / Keywords
急性缺血性卒中；阿替普酶；静脉溶栓；出血转化；预测模型
Related articles / 相关文献
相似文献
作者发文
机构发文
关键词分析
相似文献（说明：与本文内容较接近的文献）
  • [1] 姜岩,逄冬.脑卒中病人发生残疾的影响因素分析[J].护理研究,2019,33(12):2130-2133.[2] XUAD,WANGYJ,WANGDZ,etal.Consensus statement on the use of intravenous recombinant tissue plasminogen activator to treat acute ischemic stroke by the Chinese Stroke Therapy Expert Panel[J].CNS Neurosci Ther,2013,19(8):543- 548. [3] JAUCH E C,SAVER J L,ADAMS H P J R，et al. Guidelines for the early management of patients with acute ischemic stroke：a guideline for healthcare professionals from the American Heart Association/ American Stroke Association[J].Stroke,2013,44(3):870-947. [4] LEVYEI,SIDDIQUIAH,CRUMLISHA,etal.First Food and Drug Administration-approved prospective trial of primary intracranial stenting for acute stroke：SARIS（stent-assisted recanalization in acute ischemic stroke）[J].Stroke,2009,40(11):3552-3556. [5] 霍晓川,高峰.急性缺血性卒中血管内治疗中国指南 2018[J].中国卒中杂志,2018,13(07):706-729. [6] 朱健行,张蓓,李亚军.急性缺血性脑卒中静脉溶栓后出血转化的研究进展[J].卒中与神经疾病,2019,26(05):638-641. [7] Yaghi S,Willey JZ,Cucchiara B,etal. Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke:A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.Stroke.2017;48(12):e343-e361. [8] Zhang J,Yang Y, Sun H,Xing Y.Hemorrhagic transformation after cerebral infarction: current concepts and challenges.Ann Transl Med. 2014;2(8):81. [9] The NINDS t-PA Stroke Study Group.Intracerebral hemorrhage after intravenous t—PA therapy for ischemic stroke[J].Stroke,1997,28(11)：2109—2118. [10] Lees KR.ECASS-II:intravenous alteplase in acute ischaemic stroke. European Co-operative Acute Stroke Study-II.Lancet.1999;353(9146):65-68. [11] von Kummer R，Brode^ckJP，Campbell BC,ela1.The Heidelberg bleeding classification:cIassification of bleeding events after ischemic stroke and reped-usion therapy[J].Stroke,2015,46fl 01:2981—2986. [12] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南 2018[J].中华神经科杂 志,2018,51(9):666-682. [13] Yaghi S,Willey JZ,Cucchiara B,etal. Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.Stroke.2017;48(12):e343-e361. [13] Jaillard A,Cornu C,Durieux A, etal.Hemorrhagic transformation in acute ischemic stroke. The MAST-E study.MAST-E Group. Stroke 1999;30:1326-32. [14] Bang OY,Saver JL,Kim SJ, etal.Collateral flow averts hemorrhagic transformation after endovascular therapy for acute ischemic stroke. Stroke 2011;42:2235-9. [15] Gao F, Sun X, Guo X, Li D, Xu GD, Miao ZR. Endovascular Recanalization of Symptomatic Nonacute Intracranial Internal Carotid Artery Occlusion: Proposal of a New Angiographic Classification. AJNR Am J Neuroradiol.2021;42(2):299-305. [16] Ogata J，Yutani C，Imakita M，et a1.Hemorrhagic infarct of the brain without a reopening of the occluded arteries in eardioembolic stroke[J].Stroke.1989，20(7)：876—883. [17] 肖洁.梗死后出血转化中基质金属蛋白酶表达及其发病机制的实验研究[D].泸州医学院,2010. [18] 徐慈航,李敬伟,朱晓蕾.急性缺血性卒中出血转化的研究进展[J].中国卒中杂志,2020,15(04):446-451. [19] 党肖萍,李亚军.缺血性脑卒中静脉溶栓后出血转化发生机制的研究进展[J].卒中与神经疾病,2019,26(06):764-766. [20] Shi K, Zou M, Jia DM, et al. tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke.Circ Res.2021;128(1):62-75. [21] Gao Y,Churilov L,Teo S,et al.Remote intracerebral haemorrhage post intravenous thrombolysis: experience from an Australian stroke centre[J].J Clin Neurosci,2015,22(2):352-356. [22] 孙瑞,朱武生.缺血性卒中溶栓后出血转化发生机制的研究进展[J].中国脑血管病杂志,2018,15(01):52-56. [23] 许雯樱,田力,李进伟,薛维爽,滕伟禹.静脉溶栓后出血性转化研究进展[J].中华神经科杂志,2019(04):334-339. [24] Sun F, Liu H, Fu HX, et al. Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke. Front Neurol. 2020;11:551157. Published 2020 Nov 3. [25] Guo Y, Yang Y, Zhou M, He L. Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous recombinant tissue plasminogen activator: a systematic review and meta-analysis. Stroke Vasc Neurol. 2018;3(4):203-208. Published 2018 May 26. [26] Nagaraja N, Tasneem N, Shaban A, etal. Cerebral Microbleeds are an Independent Predictor of Hemorrhagic Transformation Following Intravenous Alteplase Administration in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018;27(5):1403-1411. [27] Luo Y, Jin H, Guo ZN, etal. Effect of Hyperhomocysteinemia on Clinical Outcome and Hemorrhagic Transformation After Thrombolysis in Ischemic Stroke Patients.Front Neurol. 2019;10:592. Published 2019 Jun 4. [28] Lou M，Safdar A，Mehdiratfa M，et al. The HAT score：a simple grading scale for predicting hemorrhage after thrombolysis[J].Neurology,2008,71(18):1417-1423. [29] Mazya M, Egido JA, Ford GA, et a1. Predicting the risk of symptomatic intracerebral hemorhage in ischemic stroke treated with intravenous alteplase: safe implementation of treatments in stroke(SITS)symptomatic intracerebral hemorrhage risk score[J].Stroke,2012, 43(6):1524-1531. [30] Strbian D, Enqelter S，Micher P，et al. Symptomatic intracranial hemorrhagem after stroke thrombolysis：the SEDAN score[J]. Ann Neurol，2012，71（5）：634-641. [31] Cucchiara B，Tanne D，Levine SR，et a1. A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke[J]. J Stroke Cerebrovasc Dis,2008,17(6):331-333. [32] Menon BK, Saver JL, Prabhakaran S, et al. Risk score for intracranial hemorrhage in patients with acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Stroke. 2012;43(9):2293-2299. [33] Strbian D,Meretoja A,Ahlhelm FJ,etal.Predicting outcome of IV thrombolysis-treated ischemic stroke patients: the DRAGON score.Neurology.2012;78(6):427-432. [34] Flint AC,Cullen SP, Faigeles BS, Rao VA. Predicting long-term outcome after endovascular stroke treatment: the totaled health risks in vascular events score. AJNR Am J Neuroradiol.2010;31(7):1192-1196
《中国学术期刊(光盘版)》电子杂志社有限公司 KDN平台基础技术由KBASE 11.0提供
© 2014-2018中国知网(CNKI) 京公网安备11010802020460号 经营性网站备案信息 互联网出版许可证 新出网证(京)字271号 京ICP证040431号