目的：探究对肝胆外科患者加强疼痛护理干预的临床效果。方法：选取在2019年1月至2021年1月本院肝胆外科收治的80例患者，随机分为观察组（疼痛护理干预）和对照组（常规护理）各40人。结果：相比于对照组（75.0%），观察组护理满意度（95.0%）较高（P<0.05）；干预后，观察组疼痛症状、心理弹性评分均较低，生活质量评分均较高（P<0.05）。结论：对肝胆外科患者加强疼痛护理干预可以获得更为理想的干预效果。 Objective: To explore the clinical effect of intensive pain nursing intervention in patients with hepatobiliary surgery.Methods: From January 2019 to January 2021,80 patients were randomly divided into observation group (pain nursing intervention) and control group (routine nursing).Results: Compared with the control group (75.0%), the nursing satisfaction of the observation group (95.0%) was higher (P <0.05), and the scores of pain symptoms and resilience were lower the quality of life scores were higher (P <0.05).Conclusion: Intensifying pain nursing intervention for patients in hepatobiliary surgery can obtain more ideal intervention effect.