目的：比较在老年精神障碍患者的治疗中奥氮平和喹硫平的应用效果。方法：研究对象选取我院在2019年12月-2020年12月期间收治的40例老年精神障碍患者，使用随机数字表法将患者分为喹硫平组和奥氮平组，每组各20例，比较两组患者的治疗效果。结果：治疗后2周、4周和6周两组患者的PANSS评分均明显下降（P<0.05），但两组患者治疗后2周、4周和6周的PNASS评分对比无明显差异（P>0.05）；奥氮平组患者的治疗有有效率和治愈率分别为90.00%和65.00%，喹硫平组患者的治疗有效率和治愈率分别为95.00%和75.00%，两组患者的治疗有效率和治愈率对比无明显差异（P>0.05）；奥氮平组和喹硫平组的不良反应发生率分别为15.00和10.00%，对比无明显差异（P>0.05）。结论：在老年精神障碍患者的治疗中奥氮平和喹硫平在治疗效果、症状改善和不良反应方面对比无明显差异两种药物的治疗效果均较为显著且两种药物安全性均较高，在临床治疗中可以根据患者具体情况和临床实际合理选择。 Objective: To compare the efficacy of olanzapine and quetiapine in the treatment of senile mental disorders.Methods:40 elderly patients with mental disorders admitted from December 2019 to December 2020 in our hospital were randomly divided into quetiapine group and olanzapine group with 20 cases in each group.Results: The PANSS scores of the two groups decreased significantly (P <0.05),但两组患者治疗后2周、4周和6周的PNASS评分对比无明显差异(P>0.05), the effective rate and cure rate of the olanzapine group were 90.00% and 65.00% respectively, and the effective rate and cure rate of the quetiapine group were 95.00% and 75.00% respectively.The incidence of adverse reactions in olanzapine group and quetiapine group was 15.00% and 10.00%, respectively (P >0.05).Conclusion: Olanzapine and quetiapine have no significant difference in treatment effect, symptom improvement and adverse reaction in the treatment of elderly patients with mental disorders.The efficacy of the two drugs is significant and the safety of the two drugs is high.The two drugs can be reasonably selected according to the patient's specific situation and clinical practice.
