目的：探讨在2型糖尿病（T2DM）中应用二甲双胍基础上，分别联合达格列净、格列齐特的效果。方法：2019年5月-2021年5月，选取我院收治的T2DM患者80例，随机分为两组，均给予二甲双胍治疗，研究组＋达格列净，对照组＋格列齐特，对比血糖指标、临床疗效及不良反应。结果：治疗后两组空腹血糖（FPG）、餐后2h血糖（2hPG）水平、血糖达标率、总有效率、不良反应发生率对比有差异（p＜0.05）。结论：在T2DM患者中采用二甲双胍＋达格列净治疗对血糖的控制情况较好，血糖达标率高，且对心肾保护作用良好。 Objective: To investigate the effect of metformin combined with dagliflozin and gliclazide in type 2 diabetes mellitus (T2DM).Methods: From May 2019 to May 2021,80 patients with T2DM who were treated in our hospital were randomly divided into two groups. The study group was treated with metformin and the control group was treated with gliclazide.Results: There were significant differences in fasting plasma glucose (FPG),2h postprandial plasma glucose (2hPG), blood glucose compliance rate, total effective rate and adverse reaction rate between the two groups (p <0.05).Conclusion: Metformin+dagliflozin treatment in patients with T2DM has a good control of blood glucose, high blood glucose rate, and good protective effect on heart and kidney.