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原发性与继发性不孕症患者人乳头状瘤病毒感染状况分析

何 晶晶, 刘 杰
徐州市妇幼保健院检验科

摘要


目的 了解原发性与继发性不孕症患者人乳头状瘤病毒(HPV)的感染状况、亚型分布。方法 采集 2017-2018 年 101 例原发性、104 例继发性不孕症患者及 315 例健康体检者宫颈脱落细胞，应用流式荧光杂交技术检测 HPV27 种亚型(低危亚型 10 种、高危亚型 17 种)。结果 不孕症患者 HPV 总感染率高于对照组(19.5％ vs 17.8％，P>0.05)。单一感染率高于多重感染(15.1％ vs 4.4％，P<0.05)，共检出 20 种型别，高危亚型累积感染率高于低危亚型(75.5％ vs 24.5％，P<0.05)，以HPV52、16、35型为主。继发性不孕症患者HPV感染率高于原发性不孕症 (23.1% vs 15.8%，P>0.05)。继发组检出 15 种 HPV 型，高危型累积感染率高于低危型(71.9％ vs 28.1％，P<0.05)，以 HPV35、16、58 型为主；原发组检出 10 种 HPV 型，高危型累积感染率亦高于低危型(80.0％ vs 19.0％，P<0.05)，以 HPV52、18、33 型为主。结论 HPV 感染与女性不孕症存在一定相关性，与继发性不孕症的关系可能更为密切，可建议对不孕症患者进行 HPV 筛查。

关键词


人乳头瘤病毒；原发性不孕症；继发性不孕症；流式荧光杂交；基因型

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参考


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DOI: http://dx.doi.org/10.18686/yxyj.v1i7.13343

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