肌钙蛋白I与新冠肺炎患者死亡率的关系：荟萃分析研究

Hesthi Krisnawati¹, Bhisma Murti¹, Yulia Dewi²
1、大学公共卫生硕士课程
2、大学医学院

摘要

背景：新冠肺炎是由严重急性呼吸综合征冠状病毒2型（新型冠状病毒）引起的一种新疾病。新冠肺炎
成为一种疫情，在将近两年的时间里导致400万人死亡。患有合并症和危险因素的新冠肺炎患者预后更差，其中之
一是心脏病。心脏病可通过肌钙蛋白I值检查。本研究旨在确定新冠肺炎患者肌钙蛋白I水平与死亡率之间的关系。
受试者和方法：这是一项系统性综述和荟萃分析，通过使用关键词：肌钙蛋白I、队列、死亡、心脏生物标志物、死
亡、冠状病毒、新冠肺炎死亡率和新冠肺炎，从Science Direct、Springer、谷歌学术和PubMed等数据库中搜索文章。
2019-2021年间发表的10篇认证文章被纳入荟萃分析。这项研究的对象是10，499名新冠肺炎患者。这项研究中的干
预是高肌钙蛋白I水平，而对照是正常的肌钙蛋白I水平。这项研究的结果是COVID-19患者的死亡率。使用Review
Manager软件5.3版对新冠肺炎患者肌钙蛋白I水平和死亡率之间的关系进行数据处理。结果：对中国、西班牙、纽约
（美国）、法国、土耳其和费城（美国）的10篇主要研究文章的荟萃分析显示，高肌钙蛋白I水平与新冠肺炎患者死亡
风险增加相关（aOR=3.07；95%CI=1.68-5.61；p

关键词

肌钙蛋白I；心脏病；死亡率；新冠肺炎

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