鼻呼出一氧化氮在嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉作用

王 再兴¹, 唐 志元¹, 魏 建芳¹, 曾宪 海*¹, 郑 坚²
1、深圳市龙岗区耳鼻咽喉医院耳鼻咽喉科;深圳市耳鼻咽喉研究所
2、深圳市龙岗区第六人民医院耳鼻咽喉科

摘要

目的 探讨鼻呼出一氧化氮在评估酸性粒细胞型慢性鼻窦炎伴鼻息肉预后中的作用、临床意义以及应用价值。方法
回顾性分析 2020 年 1 月-2022 年 1 月在深圳市龙岗区耳鼻咽喉医院就诊的慢性鼻窦炎伴鼻息肉患者 42 例，均行功能性鼻内
镜手术，分为无复发组（ECRSwNP）和复发组（REECRSwNP），比较两组手术前后 nNO、VAS 评分、鼻内镜 Lund-Kennedy
评分、外周血嗜酸性粒细胞百分比，双侧鼻息肉组织嗜酸性粒细胞个数（本研究仅仅是进行了组间比较，体现不了鼻呼出一
氧化氮价值，设计还不够）。结果 42 例患者中复发 12 例，复发率 28.57%，ECRSwNP 组术后 1 年的 nNO 水平、VAS 评
分、鼻内镜 Lund-Kennedy 评分低于术前，具有统计学差异（P<0.05）；RECRSwNP 组术后 1 年的 nNO 水平、VAS 评分无
统计学差异（P>0.05）；RECRSwNP 组术后 1 年的鼻内镜 Lund-Kennedy 评分低于术前，具有统计学差异（P<0.05）。ECRSwNP
组术前的 nNO 水平低于 RECRSwNP 组，具有统计学差异（P<0.05）；ECRSwNP 组与 RECRSwNP 组术前的 VAS 评分无统
计学差异（P>0.05）；ECRSwNP 组术后 1 年的 nNO 水平、鼻内镜 Lund-Kennedy 评分低于 RECRSwNP 组，具有统计学差异
（P<0.05）。ECRSwNP 组 PB-EOS%、T-EOS 均低于 RECRSwNP 组，具有统计学差异（P<0.05）；两组 PB-EOS%、T-EOS
分别与 nNO 水平呈负相关。结论 nNO 可作为潜在的评估指标之一，协助判断嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉的预后。

关键词

嗜酸性粒细胞型慢性鼻窦炎；鼻息肉；鼻呼出一氧化氮

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