孕早期产前血清学指标与不良妊娠结局关系的研究进展

曾 敏
赣州市人民医院产科

摘要

产前血清学筛查是指通过经济、简便、无创的检测方法，主要对唐氏综合征及其他染色体异常胎儿的发病风险进行评估，对高风险者进行产前诊断，最大限度地保障出生人口素质。目前国内外很多研究表明，异常的产前血清学指标不单可以筛查唐氏综合征、18三体，还与很多不良妊娠结局有关[1]，提示异常的产前血清学筛查指标对不良妊娠结局有预测判断的作用。不良妊娠结局可以危及孕妇及胎儿生命，会给家庭和社会带来沉重的负担。本文主要对早孕期异常血清学指标与不良妊娠结局相关的研究进展进行综述。

关键词

孕早期；产前血清学指标；不良妊娠；研究进展

参考

[1]张檀.孕中期血清产前筛查与不良妊娠结局的相关性分析[J].中华医学遗传学杂志,2012,5(29):45-46. [2]LIU S S,LEE F K,LEE J L,et al.Pregnancy outcomes in unselected singleton pregnant women with an increased risk of first-trimester Down's syndrome[J].Acta obstetricia et gynecologica Scandinavica,2004,83(12):1130-1134. [3]DUGOFF L.First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes [J].Obstetrics and gynecology,2010,115(5):1052-1061. [4]D'ANTONIO F,RIJO C,THILAGANATHAN B,et al.Association between first-trimester maternal serum pregnancy-associated plasma protein-A and obstetric complications [J]. Prenatal diagnosis,2013,33(9):839-847. [5]ODIBO A O,ZHONG Y,GOETZINGER K R,et al. First-trimester placental protein 13, PAPP-A, uterine artery Doppler and maternal characteristics in the prediction of pre-eclampsia [J].Placenta,2011,32(8):598-602. [6]杨昕.妊娠早期孕妇血清PAPP-A水平与妊娠并发症的相关性分析 [J].中国产前诊断杂志（电子版）,2011,2(03):56-58. [7]KARSIDAG A Y,BUYUKBAYRAK E E,KARS B,et al.The relationship between unexplained elevated serum markers in triple test, uterine artery Doppler measurements and adverse pregnancy outcome [J].JPMA The Journal of the Pakistan Medical Association,2010,60(3):181-186. [8]杨鸿.孕中期血β-人绒毛膜促性腺激素水平与不良妊娠结局的关系[J].检验医学与临床,2010,17(07):98-100. [9]吴红.早孕期唐氏筛查中孕妇血清标志物对妊娠结局影响的研究[D].广东:广州医科大学,2013. [10]LOECHEL F,FOX J W,MURPHY G, et al.ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3[J].Biochemical and biophysical research communications,2000,278(3):511-515. [11]MAKRYDIMAS G,SOTIRIADIS A,SPENCER K,et al.ADAM12-s in coelomic fluid and maternal serum in early pregnancy [J].Prenatal diagnosis,2006,26(13):1197-1200. [12]戚红.妊娠早期孕妇血清解整合素-金属蛋白酶12水平变化与妊娠结局[J].中华妇产科杂志,2009,6(44):62-63. [13]MAJUMDAR S DAHIYA R,MAPA M K,et al.Circulating levels of pregnancy specific beta 1-glycoprotein in normal & pathological pregnancies[J].The Indian journal of medical research,1984(79):630-635. [14]ISRAFILBEILI F R.[The correlation between pregnancy specific beta-1 glycoprotein and cytokines in post-dated pregnancy[J].Georgian medical news,2006,138):29-33. [15]邹琳.胎儿生长受限孕妇血浆、胎盘、羊水中妊娠特异性β1糖蛋白(SP1)与胎盘功能的研究[J].临床医学工程,2010,8(17):71-73.