阿芬太尼的临床应用进展

吴 影¹, 刘 枫¹, 刘 红梅², 张 静怡²
1、华北理工大学
2、唐山工人医院

摘要

阿芬太尼是合成的作用于μ阿片受体的激动剂，为短效强镇痛药。相比于芬太尼和瑞芬太尼等相似的麻醉药品，阿芬太尼的效价低，起效快，作用时间较短。静脉注射后1.4分钟作用达峰，维持时间约15分钟，分布容积小，经肝脏代谢后经肾脏排出。阿芬太尼用药后，呼吸循环的抑制率较低，呛咳反应少，血流动力学的波动较小，术后恶心呕吐发生率低。在国外，广泛应用于门诊手术和日间手术的麻醉。相对于其他芬太尼类的药物来说，具有明显的优势。，但目前阿芬太尼的临床应用经验和相关研究有限。本文就阿芬太尼的药理作用特点及在国内外的应用进展稍作总结。

关键词

阿芬太尼；药理；临床应用

参考

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