NG 及 NFL 在创伤性颅脑损伤中的研究进展

曾 艺煌¹, 罗 文哲¹, 雅 琦¹, 盛延 良1²
1、佳木斯大学基础医学院
2、佳木斯大学基础医学院涂泉韬佳木斯大学附属第一医院病理科

摘要

创伤性颅脑损伤是临床及法医学案例中致死、致残的主要原因之一。然而在创伤性颅脑损伤的临床诊断和鉴定中缺少一定的生物标记物，使创伤性颅脑损伤的诊断治疗和鉴定面临一定困难。神经颗粒素(NG)是一种神经元特异性突触后蛋白，神经丝轻链蛋白(NFL)是神经丝结构的重要主体结构，NG 和 NFL 在中枢神经系统的生理和病理过程中发挥着不可或缺的作用，有研究表明它们在创伤性颅脑损伤中也发挥着不同的作用,本文重点从 NG、NFL 的功能作用、在创伤性颅脑损伤后表达等予以综述。

关键词

创伤性颅脑损伤;NG;NFL;综述

参考

[1] Yuan A, Rao MV, Veeranna, et al. Neurofilaments andNeurofilament Proteins in Health and Disease[J]. Cold SpringHarbor perspectives in biology, 2017, 9(4). [2] Singec I, Knoth R, Ditter M, et al. Neurogranin isexpressed by principal cells but not interneurons in the rodent andmonkey neocortex and hippocampus [J]. J Comp Neurol, 2010, 479(1): 30-42. [3] Watson J, Battenberg E, Wong K, et al. Subtractive cDNAcloning of RC3, a rodent cortex-enriched mRNA encoding a novel78 residue protein [J]. J Neurosci Res, 1990, 26(4): 397-408. [4] YangJ, KodeyFK,DaiM,eta1.Serum neurogranin measurement as a biomarker of acute tramatic brain injury[J].ClinBiochem,2015,48(13.14):843-848. [5] Dorsett C R, Mcguire J L, Depasquale E, et al. Glutamateneurotransmission in rodent models of traumatic brain injury[J]. Journal of Neurotrauma, 2016:263.[6] Vos A, Bjerke M, Brouns R, et al. Neurogranin and tau incerebrospinal fluid and plasma of patients with acute ischemicstroke [J]. BMC Neurol, 2017, 17(1): 170-177. [7] 张群,etal.,神经丝轻链蛋白与神经系统疾病[J].中风与神经疾病杂志.2019.36(04):380-382. [8] I. Fyfe, Neurofilament light chain-new potential forprediction and prognosis[J]. Nat Rev Neurol. 2019. 15(10):557. [9] L. Gaetani, et al., Neurofilament light chain as abiomarker in neurological disorders[J]. J Neurol NeurosurgPsychiatry. 2019. 90(8):870-881. [10] SKILLBACK T,FARAHMAND B, BARTLETT J W, etal . CSF neurofilament light differs in neurodegenerative diseasesand predicts severity and survival [J]. Neurology, 2014, 83(21): 1945-1953.