他汀类药物诱导的中毒性横纹肌溶解症伴肝细胞性黄疸

C· 雅各, 卡提 克·, 莫汉 ·詹, 拉姆 亚·
印度泰米尔纳德邦韦洛尔 CMC 第五医学部

摘要

药物不良反应(ADR)是老年人住院、发病率和死亡率增加的常见原因。ADR 很难在老年人中诊断，因为他们经常出现非特异性症状，如疲劳、跌倒、认知能力下降和便秘。他汀类药物通常是用于冠状动脉疾病二级预防的耐受性良好的药物。我们报告了一名 75 岁的女士，她在开始使用 40mg 阿托伐他汀治疗冠状动脉疾病后，因他汀类药物引起的肝炎和急性横纹肌溶解导致近端肌病而出现黄疸并卧床不起。停止他汀类药物治疗和支持治疗后，她的临床症状迅速改善。在评估疾病时，必须将 ADR 视为老年患者鉴别诊断的一部分。在开始服用他汀类药物的老年人中，必须区分良性肌肉疼痛和伴有生化异常的严重肌肉损伤。立即停用他汀类药物将导致快速改善并防止进一步恶化。

关键词

肝炎;横纹肌溶解症;他汀类药物

参考

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