微小 RNA 在银屑病免疫调节机制中的研究进展

赵 宗峰, 朱 健, 陆 晟, 吴 秀娟
上海市徐汇区中心医院皮肤科

摘要

目的：银屑病是一种遗传与环境因素共同作用诱发的免疫介导的慢性、炎症性、免疫性、系统性疾病，其临床症
状表现为红斑、鳞屑性病变。microRNA 是一种短的、非蛋白质编码的调节小 RNA，在银屑病发病机制起重要作用。微
小 RNA 参与细胞增殖、分化、凋亡及器官形成和发育等多种生物学过程、参与机体免疫调节，并作为抑制或降解靶信使
RNA 的转化因子。在银屑病中，microRNAs 在基因水平发挥了重要的调控作用。为了深入了解银屑病中 microRNAs 的生
物学功能，查阅相关文献进行总结。

关键词

银屑病，miRNA；免疫调节

参考

[1]Zhao M,Lu Q.The aberrant epigenetic modificatios in the pathogenesis of psoriases[J].I investing Dermatol Symp Proc,2018,19(2):S81-S82.

[2] Kozomara A,Birgaoanu M,Griffiths-Jones S.miRBase:from microRNA sequences to function[J].Nucleic Acids Res,2019,47(D1):D155-D162．

[3] Alcantara C，Reiche E，Sim o A. Cytokines in psoriasis[J].Adv Clin Chem,2021,138(100):171-204.

[4] Yang Xiuli,Wang Honglin.miRNAs Flowing Up and Down: The Concerto of Psoriasis[J].Frontiers in Medicine,2021,8(2):646796.

[5] SRIVASTAVA A,NIKAMO P,LOHCHAROENKAL W,et a1.MicroRNA-146a suppresses IL-17-mediated skin in flammation and is genetically associated with psoriasis [J]．J Allergy Clin Immunol,2017,139(2):550-561.

[6]Yang Xiuli,Wang Honglin.miRNAs Flowing Up and Down: The Concerto of Psoriasis[J].Frontiers in Medicine,2021,8(2):646796.

[7]Abdallah F, Henriet E, Suet A, Arar A, Clemençon R, Malinge JM, Lecellier G, Baril P, Pichon C.miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response[J].Cells,2021,10 (10):2547-2568.

[8]Hruska P, Kuruczova D, Vasku V, BienertovaVasku J.MiR-21 binding site SNP within ITGAMassociated with psoriasis susceptibility in women[J].PLoS One,2019,14(6):e0218323.

[9] 刘瑞风 , 杨晓红 , 梁见楠 , 张开明 , 银屑病患者皮损间充质干细胞环状 RNA 表达异常研究 [J]. 中华皮肤科杂志 ,2018,51(10):723-728.

[10] 李锘 , 押丽静 , 王磊 , 王英 , 白彦萍 . 清热凉血方对咪喹莫特诱导银屑病样小鼠模型 Th17/Treg 细胞失衡的影响及 miR-210 激动剂的干预作用 [J]. 北京中医药学大学学报 ,2018,42(11):910-917.

[11]Zibert J.R.,Lovendorf M.b.,Litman T.,et al.MicroRNAs and potential target interactions in psoriasis[J].J Dermatol Sci,2010,58(3):177-185.

[12]Min Pan,Yao Huang,Xiaofang Zhu,Xiangfei Lin,Dan Luo.miR125bmediated regulation of cell proliferation through the Jagged1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis[J].Mol Med Rep,2019,19(6):5227-5236.

[13]Wang, M.J.,Xu, Y.Y.,Huang, R.Y.,et a1.Role of an imbalanced miRNAs axis in pathogenesis of psoriasisnovel perspectives based on review of the literature[J].oncotarget,2017,8(3):5498-5507.

[14]Alatas E.t., Kara M.,Dogan G.,er al.Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity[J].An Bras Dermatol,2020,95(6):702-707.