乳果糖联合开塞露在脑梗死后便秘中的临床疗效

李 　丹, 吴 红芳
容城县人民医院

摘要

目的：探讨乳果糖联合开塞露在治疗脑梗死后便秘中的应用疗效。方法：以 80 例既往无便秘病史，急性脑梗死
后出现功能性便秘患者为受试对象，采用随机对照法将其随机分为两组。对照组采取肛门注入开塞露，研究组在其基础上
联合口服乳果糖治疗。比较两组治疗有效率。结果：研究组的总有效率达 95.00%，与对照组的 85.00% 相比有显著性差异
（P<0.05）；两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：脑梗死后便秘采用口服乳果糖联合肛门注
入开塞露治疗效果更佳，无明显副作用，值得临床推广应用。

关键词

乳果糖；开塞露；便秘；脑梗死

参考

[1]Michael Camilleri.Gastrointestinal motility disorders in

neurologic disease[J].J Clin Invest. 2021 Feb 15; 131(4): e143771.

[2]Li J, et al. Incidence of constipation in stroke

patients: a systematic review and meta-analysis[J]. Medicine

(Baltimore) 2017;96(25):e7225.

[3]Sayama T, Suzuki S, Fukui M. Expression of

inducible nitric oxide synthase in rats following subarachnoid

hemorrhage. Neurol Res. 1998;20:79–84. doi: 10.1080/0161641

2.1998.11740488.

[4]Wesselius-De Casparis A, Braadbaart S, Bergh-Bohlken

GE, Mimica M. Treatment of chronic constipation with lactulose

syrup: results of a double-blind study[J]. Gut. 1968 Feb;9(1):84-6.

[5]Portalatin M, Winstead N. Medical management of

constipation[J]. Clin Colon Rectal Surg. 2012 Mar;25(1):12-9.

[6]Elkington SG. Lactulose[J]. Gut. 1970 Dec;11(12):1043-8.

[ 7 ] C h e n g J , e t a l . P o s t s t r o k e c o n s t i p a t i o n i s

associated with impaired rectal sensation[J]. A m J

Gastroenterol. 2020;115(1):105–114.

[8]Travagli RA, et al. Brainstem circuits regulating gastric

function[J]. Annu Rev Physiol. 2006;68:279–305.

[9]Yi JH, et al. Bowel function in acute stroke patients[J]. Ann

Rehabil Med. 2011;35(3):337–343.

[10]Michael Camilleri.Gastrointestinal motility disorders in

neurologic disease[J].J Clin Invest. 2021 Feb 15; 131(4): e143771.

[11] Lactulose Clinical Cooperation Group, Zhu ZZ. A

randomized, double-blind, placebo-controlled multicenter clinical

study of lactulose in the treatment of constipation in pregnant

women[J]. Chinese Journal of Digestion 2006;(10):690-3.