抑郁症中的炎症和抗炎治疗的潜力

石田 考拉¹, 古文 德·¹, 阿米 尔·¹, 安妮 莎·¹, 卡托 ·克¹, ²
1、医学工程研究所
2、

摘要

越来越多的证据支持抑郁症和炎症过程之间的关联，这种联系似乎是双向的。临床试验表明抗炎药的抗抑
郁治疗效果，无论是作为附加治疗还是作为单一疗法。特别是，与安慰剂相比，非甾体抗炎药（NSAID）和细胞因
子抑制剂已显示出抗抑郁治疗效果，但他汀类药物、多不饱和脂肪酸、吡格列酮、米诺环素、莫达非尼和皮质类固
醇也可能产生抗抑郁治疗效果。然而，炎症级联反应的复杂性、有限的临床证据以及副作用的风险在临床应用前强
调谨慎。因此，尽管对抑郁症的抗炎治疗效果进行了概念验证研究，但仍有待研究的重要挑战。在本文中，我们回
顾了炎症和抑郁症之间的关联，以及目前关于在抑郁症中使用抗炎治疗的证据。基于此，我们解决了似乎最重要和
与未来研究相关的问题和挑战，例如时间安排、最有效的治疗时间和确定可能对不同抗炎治疗方案有更好反应的患
者亚组。

关键词

抗抑郁药；抗炎治疗；塞来昔布；细胞因子抑制剂；抑郁症；炎症；他汀类药物

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