肠瘘与腹腔感染炎性因子关系的研究进展

孟 波
唐山市工人医院胃肠外一科

摘要

肠瘘是指各种原因引起的胃肠道与腹腔或皮肤之间存在的异常通道,胃肠道内容物从该通道外漏到其他器官､体腔或体表外,从而导致机体继发感染､体液损失､内环境平衡失衡､器官功能损伤､营养不良､出血､多器官功能障碍等一系列问题[1]｡同时也是腹部胃肠道手术后最为常见和最严重的并发症,分为肠内瘘和肠外瘘[2]｡腹腔感染(intra-abdominalinfections,IAIs)是一种常见的外科疾病,也是一种常见的术后并发症,是肠瘘患者最主要的感染之一[3],可导致患者的血流动力学､呼吸和代谢等功能紊乱,若未能及时治疗,可并发脓毒症､感染性休克､胃肠道出血及急性呼吸窘迫综合征等情况[4],可导致多种器官功能衰竭,一旦发生,处理困难,恢复率低且死亡率高[5]｡一方面会导致患者的住院时间延长,病程一般持续数月至半年之久,另一方面,医疗费增加,导致不必要的经济损失｡沉重的经济负担使患者普遍存在焦虑､恐惧､抑郁等负面情绪,因此,对腹腔感染相关的肠瘘进行早期诊断和及时有效的干预治疗,可改善患者预后｡炎性细胞因子身为炎症传导因子,可反映早期感染程度,并在腹腔感染相关的肠瘘的发生和发展中起着重要作用｡探索炎性因子的改变,对于诊断和治疗以及有效降低肠瘘发病率和死亡率都具有重要的临床意义｡

关键词

肠瘘､腹腔感染､炎性因子

参考

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