长链非编码RNALINC01006与非小细胞肺癌顺铂耐药的关系

赵 恒宇¹, 金 舒怡¹, 邱 善婷¹, 吴 佳锜², 慕 明珊², 陆 屹松², 李 晓燕²
1、杭州医学院临床医学院
2、杭州医学院基础医学与法医学院

摘要

目的探究LINC01006与非小细胞肺癌顺铂耐药的关系｡方法通过GSE43493和GSE108139数据集筛选参与肺癌顺铂耐药的核心基因,明确核心基因的表达情况｡富集分析明确核心基因的生物学功能｡探究核心基因的表达差异､诊断效能及预后意义｡通过实时荧光定量PCR检测LINC01006表达｡结果核心基因主要参与磷酸肌醇信号通路及染色体结构的调节,肺癌化疗患者预后不良相关｡LINC01006有一定的诊断效能,在肺癌顺铂耐药细胞中高表达｡结论LINC01006在非小细胞肺癌顺铂耐药细胞中高表达｡

关键词

肺癌;非小细胞肺癌;LINC01006;顺铂;耐药

参考

[1]LIANGW,HEJ,SHENY,等.ImpactofExaminedLymphNodeCountonPreciseStagingandLong-TermSurvivalofResectedNon-Small-CellLungCancer:APopulationStudyoftheUSSEERDatabaseandaChineseMulti-InstitutionalRegistry.[J/OL].Journalofclinicaloncology_x001f_:officialjournaloftheAmericanSocietyofClinicalOncology,2017,35(11):1162-1170.DOI:10.1200/JCO.2016.67.5140.[2]KADARAH,CHOIM,ZHANGJ,等.Whole-exomesequencingandimmuneprofilingofearly-stagelungadenocarcinomawithfullyannotatedclinicalfollow-up.[J/OL].Annalsofoncology_x001f_:officialjournaloftheEuropeanSocietyforMedicalOncology,2017,28(1):75-82.DOI:10.1093/annonc/mdw436.[3]SUNGH,FERLAYJ,SIEGELRL,等.GlobalCancerStatistics2020:GLOBOCANEstimatesofIncidenceandMortalityWorldwidefor36Cancersin185Countries.[J/OL].CA:acancerjournalforclinicians,2021,71(3):209-249.DOI:10.3322/caac.21660.[4]INAMURAK.ClinicopathologicalCharacteristicsandMutationsDrivingDevelopmentofEarlyLungAdenocarcinoma:TumorInitiationandProgression.[J/OL].Internationaljournalofmolecularsciences,2018,19(4).DOI:10.3390/ijms19041259.[5]荣辉,程蒙蒙,佘明金,等.复方苦参注射液联合铂类一线化疗方案对非小细胞肺癌患者的临床疗效[J].中华肺部疾病杂志(电子版),2021,14(1):98-100.[6]ZHANGY,LIUH,ZHANGQ,等.LongNoncodingRNALINC01006FacilitatesCellProliferation,Migration,andEpithelial-MesenchymalTransitioninLungAdenocarcinomaviaTargetingtheMicroRNA129-2-3p/CTNNB1AxisandActivatingWnt/β-CateninSignalingPathway[J/OL].MolecularandCellularBiology,2021,41(6):e00380-20[2023-03-25].https://doi.org/10.1128/MCB.00380-20.DOI:10.1128/MCB.00380-20.[7]国家卫生健康委办公厅.原发性肺癌诊疗指南(2022年版)[J/OL].协和医学杂志,2022,13(4):549-570[2023-03-25].https://kns.cnki.net/kcms2/article/abstract?v=3uoqIhG8C44YLTlOAiTRKibYlV5Vjs7iJTKGjg9uTdeTsOI_ra5_XTAxoc5fNT_pQZQ1fpBSjbOeId3EEVybdP0fkmtGnI3V&uniplatform=NZKPT.