SARS-CoV-2与其他人类冠状病毒的交叉免疫反应:对疫苗研发的启示

王 鑫¹, 郭 源源¹, 杨 晓楠²
1、山东大学公共卫生学院;中国疾病预防控制中心病毒病预防控制所
2、山东大学公共卫生学院

摘要

由严重急性呼吸系统综合症冠状病毒2型(SARS-CoV-2)引起的新冠疫情已经对全球公共卫生和经济造成了严重的影响｡SARS-CoV-2在世界范围内的传播已经改变了人群的基线免疫背景,但是SARS-CoV-2对其他人类冠状病毒建立的反向预存免疫屏障仍不十分清楚｡因此,本文总结了SARS-CoV-2与其他严重急性呼吸综合症冠状病毒(SARS-CoV和MERS-CoV)､普通感冒冠状病毒(OC43､HKU1､229E和NL63)之间的交叉免疫反应,为后续的相关研究以及广谱冠状病毒疫苗的研发提供有用的信息｡

关键词

新冠病毒;冠状病毒;交叉反应;疫苗

参考

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