巨噬细胞在器官移植中作用的研究进展

张 译中, 高 良辉
海南医学院第一附属医院

摘要

器官移植是治疗终末期疾病和不可逆器官衰竭的最佳手段之一,随着器官移植技术的成熟和免疫抑制剂的发展,器官移植的短期生存率得到了显著的提升｡然而,移植物远期生存率仍然是器官移植学科亟待解决的主要问题｡越来越多的动物和临床研究表明,单核细胞和巨噬细胞在器移植物的免疫排斥反应及免疫耐受中发挥关键作用,因为这些单核吞噬细胞识别异体抗原,并触发炎症级联反应,激活适应性免疫应答｡本文将深入研究巨噬细胞的多样性､可塑性,以及其在器官移植中的作用,为改善器官移植预后提供一个新的方向｡

关键词

巨噬细胞;器官移植;免疫排斥反应;免疫耐受

参考

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