强化口服水化预防造影剂肾病的执行率与有效性研究

詹 晓燕, 林 丽霞, 黄 嘉熙, 陈 壁铭

摘要

目的：是探讨强化口服水化的执行率对 PCI 后患者的影响，从而预防造影剂肾病的发生。研究方法是随机将 560 位患者平均分为对照组和实验组，对照组急诊 PCI 后 6h 内按 1ml/kg/h 速度口服蒸馏水总量水化急；实验组急诊 PCI 术后，强化口服水化的执行率，严格执行 6h 内按 3ml/kg/h 速度口服蒸馏水水化（EF<40%或者 Killip 分级>1 级者速度减半）。实验结果为急诊 PCI 术后 6h 尿量实验组为 953.8（±527.5）显著高于对照组 649.0（±412.8），p<0.0001；两组 72hCIN 发生率，实验组 11 例，占入选病例 10.19%，对照组 59 例，占入选病例 21.85%；对照组 CIN 发生显著高于实验组（P＜0.05）。结论是急性 PCI 术后强化口服水化的执行率（饮水 100-150ml/次），可以有效预防 CIN 的发病率，且简便经济，利于减轻患者经济负担。

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