亨廷顿病：免疫观点

安纳 普尔, 拉菲 亚·, 苏尼 尔·, 多梅 尼科, 乌代 ·博
意大利特伦托

摘要

亨廷顿病（HD）是一种进行性神经退行性疾病，由 CAG三核苷酸重复序列的异常扩增引起。神经炎症是
大多数神经退行性疾病的典型特征，会导致大脑受影响区域出现一系列病理变化。HD中的神经变性也是由在聚集的
突变亨廷顿蛋白存在下的异常免疫反应引起的。免疫激活对HD神经系统的影响是一个相对未探索的研究领域。本
文总结了与HD发展和进展相关的免疫学特征。

关键词

亨廷顿病；神经炎症；病理

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