浅析糖尿病与牙周炎分子机制的相关现状

任 存贵
甘肃省华亭市第一人民医院

摘要

糖尿病和牙周炎是日常生活常见的疾病，严重降低了患者的生活质量。糖尿病与牙周炎双向关系的相关研
究是近年来研究的主要焦点之一，但其关联机制仍有待进一步验证。本文从线粒体功能障碍和氧化应激的角度对糖
尿病与牙周炎的相关性进行综述。

关键词

糖尿病；牙周炎；线粒体功能障碍；氧化应激

参考

[1] Bascones-Martínez A, Muñoz-Corcuera M, Bascones-

Ilundain J. Diabetes y periodontitis: una relación bidireccional

[J]. Med Clin (Barc). 2015 ;145(1):31-5.

[2] Chávarry NG, Vettore MV, Sansone C, Sheiham A.

The relationship between diabetes mellitus and destructive

periodontal disease: a meta-analysis[J]. Oral Health Prev Dent.

2009;7(2):107-27.

[3] Preshaw PM, Alba AL, Herrera D, et al,. Periodontitis

and diabetes: a two-way relationship[J]. Diabetologia. 2012

;55(1):21-31.

[4] Nascimento GG, Leite FRM, Vestergaard P, Scheutz F,

López R. Does diabetes increase the risk of periodontitis? A

systematic review and meta-regression analysis of longitudinal

prospective studies. Acta Diabetol. 2018 Jul;55(7):653-667.

[5] Artese HP, Foz AM, Rabelo Mde S, Gomes GH,

Orlandi M, Suvan J, D'Aiuto F, Romito GA. Periodontal

therapy and systemic inflammation in type 2 diabetes mellitus:

a meta-analysis. PLoS One. 2015;10(5):e0128344.

[6] Bullon, P.; Cordero, M.D.; Quiles, J.L.; Morillo,

J.M.; Ramirez-Tortosa, M.D.C.; Battino, M. Mitochondrial

dysfunction promoted by Porphyromonas gingivalis

lipopolysaccharide as a possible link between cardiovascular

disease and periodontitis. Free Radic.Biol. Med. 2011, 50,

1336–1343.

[7] van Niekerk G, Davis T, Patterton HG, Engelbrecht

AM. How Does Inflammation-Induced Hyperglycemia Cause

Mitochondrial Dysfunction in Immune Cells? Bioessays. 2019

;41(5):e1800260.

[8] Zarse K, Ristow M. Mitochondrial ROS signals prevent

excessive immune response. Nat Metab. 2021 May;3(5):588-

589.

[9] mitochondria are relevant sources of superoxide anion

in the oxinflammatory response of macrophages exposed to

airborne particulate matter. Ecotoxicol Environ Saf. 2020 Dec

1;205:111186.

[10] Nonaka K, Bando M, Sakamoto E, Inagaki Y,

Naruishi K, Yumoto H, Kido JI. 6-Shogaol Inhibits Advanced

Glycation End-Products-Induced IL-6 and ICAM-1

Expression by Regulating Oxidative Responses in Human

Gingival Fibroblasts. Molecules. 2019 Oct 15;24(20):3705.

[11] Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ.

Evaluating All Potential Oral Complications of Diabetes

Mellitus. Front Endocrinol (Lausanne). 2019 18;10:56.

[12] Pietropaoli D, Tatone C, D'Alessandro AM, Monaco

A. Possible involvement of advanced glycation end products

in periodontal diseases. Int J Immunopathol Pharmacol. 2010

Jul-Sep;23(3):683-91.

[13] Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y,

Dong W. ROS and ROS-Mediated Cellular Signaling. Oxid

Med Cell Longev. 2016;2016:4350965.

[14] Zhang J, Wang Y, Liu X, Dagda RK, Zhang Y. How

AMPK and PKA Interplay to Regulate Mitochondrial Function

and Survival in Models of Ischemia and Diabetes. Oxid Med

Cell Longev. 2017;2017:4353510.

[15] He L, Zhou X, Huang N, Li H, Tian J, Li T, Yao K,

Nyachoti CM, Kim SW, Yin Y. AMPK Regulation of Glucose,

Lipid and Protein Metabolism: Mechanisms and Nutritional

Significance. Curr Protein Pept Sci. 2017;18(6):562-570.

[16] Madhavi YV, Gaikwad N, Yerra VG, Kalvala AK,

Nanduri S, Kumar A. Targeting AMPK in Diabetes and

Diabetic Complications: Energy Homeostasis, Autophagy and

Mitochondrial Health. Curr Med Chem. 2019;26(27):5207-

5229.

[17] Yasunaga, M.; Kajiya, H.; Toshimitsu, T.;

Nakashima, H.; Tamaoki, S.; Ishikawa, H.; Maeda, H.; Ohno,

J. The Early Autophagic Pathway Contributes to Osteogenic

Differentiation of Human Periodontal Ligament Stem Cells. J.

Hard Tissue Biol. 2019, 28,63–70.

[18] Herzig S, Shaw RJ. AMPK: guardian of metabolism

and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018

Feb;19(2):121-135.