人免疫缺陷病毒患者巨细胞病毒感染继发的吞噬细胞综合征

Elizabeth Castro, María Cepeda, Diego Ospina
委内瑞拉马 拉开波 祖利亚大学医学院

摘要

目的：吞噬血细胞综合征（HPS）或吞噬血淋巴细胞增多症的特征是免疫系统失调，巨噬细胞和T淋巴细胞活化，这
是对不同刺激的不可控和过度炎症反应的产物。本文介绍了一例在当前治疗下有人类免疫缺陷病毒（HIV）病史的患者，
其临床表现为发热、厌食和乏力，身体检查皮肤黏膜苍白、脱水、全身性淋巴结病、肝脾肿大。进行了临床旁试验，表明
巨细胞病毒（CMV）再次激活感染，此外，在其住院期间，发现明显的全血细胞减少症，铁蛋白值升高，进行骨髓活检，
观察组织细胞增殖，患者符合组织细胞学会2004年提出的HPS诊断标准，治疗开始了，但它呈现出迟钝的演变，最终导致
死亡。结论：HPS诊断复杂；它通常与潜在疾病重叠，这是CMV感染再激活的HIV患者的情况；这两种病毒本身都与HPS
有关；因此，了解该实体的临床和实验室标准对于早期诊断和及时治疗至关重要，从而降低死亡率。

关键词

噬血细胞综合征；噬血细胞淋巴瘤；巨细胞病毒；人类免疫缺陷病毒

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