普鲁士蓝协同药物递送的抗癌作用效应研究进展

刘 爽, 陈 星宇, 侯 雪, 阚 玉萍, 阎 雪莹
黑龙江中医药大学药学院

摘要

普鲁士蓝（PB）是一种具有独特物理、化学、光学和磁性特性的材料。普鲁士蓝纳米颗粒（PBNPs）具有合成简单可调控、易于表面功能化、稳定性良好、载药率较高以及具备靶向性等优势。此外，PBNPs拥有较大的比表面积和较高的光热转换效率，因此在生物医学领域，特别是肿瘤治疗方面广泛应用。本文对PBNPs在癌症治疗中的应用进行总结，提出了在癌症治疗中的潜在挑战和前景。这些研究进展揭示了PBNPs在癌症治疗领域的巨大潜力。

关键词

普鲁士蓝；纳米材料；光热特性；癌症治疗

参考

[1] KEGGIN, J., MILES, F. Structures and Formulæ of the Prussian Blues and Related Compounds. Nature 137, 577–578 (1936).

[2] Patra CR. Prussian blue nanoparticles and their analogues for application to cancer theranostics. Nanomedicine (Lond). 2016 Mar;11(6):569-72.

[3] Busquets MA, Estelrich J. Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications. Drug Discov Today. 2020 Aug;25(8):1431-1443.

[4] Tian H, Guo Z, Chen J, et al. PEI conjugated gold nanoparticles: efficient gene carriers with visible fluorescence[J]. Advanced healthcare materials, 2012, 1(3): 337-341.

[5] Mohammad A, Faustino PJ, Khan MA, Yang Y. Long-term stability study of Prussian blue - a quality assessment of water content and thallium binding. Int J Pharm. 2014 Dec 30;477(1-2):122-7.

[6] Mohammad A, Yang Y, Khan MA, Faustino PJ. A long-term stability study of Prussian blue: A quality assessment of water content and cesium binding. J Pharm Biomed Anal. 2015 Jan 25;103:85-90.

[7] Center for Disease Control.Available online:https://emergency.cdc.gov/radiation/prussianblue.asp(accessed on 11 June 2018).

[8] Tong X, Srivatsan A, Jacobson O, Wang Y, Wang Z, Yang X, Niu G, Kiesewetter DO, Zheng H, Chen X. Monitoring Tumor Hypoxia Using (18)F-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy. Sci Rep. 2016 Aug 22;6:31551.

[9] Hu X, Mei S, Meng W, Xue S, Jiang L, Yang Y, Hui L, Chen Y, Guan MX. CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance. Cancer Lett. 2018 Jul 1;425:1-12.