评估含利多卡因注射用修饰透明质酸钠凝胶纠正鼻唇沟皱纹的注射疼痛改善效果
摘要
目的：评估含0.3%盐酸利多卡因的透明质酸凝胶（HA-L）在鼻唇沟皱纹矫正中的镇痛效果与临床价值。
方法：本研究通过双盲自身对照试验，纳入40例双侧中度至重度鼻唇沟皱纹女性患者（44±11岁），采用分层注射技术（每侧≤1.5mL），左侧注射HA-L（20mg/mL透明质酸钠+3mg/mL利多卡因），右侧注射常规HA凝胶。
结果：HA-L组即刻疼痛VAS评分较对照组降低48.8%（2.02±1.86 vs 3.95±2.11，p<0.001），镇痛效应持续60分钟。两组术后14天WSRS改善率均为100%（评分均提升≥1分），GAIS满意率无差异（95.0% vs 97.5%，p>0.05）。同时，HA-L组疼痛相关不良反应减少17.6%（35.0% vs 42.5%），且未增加肿胀、硬结等风险（p>0.05）。
结论：含0.3%利多卡因的透明质酸凝胶通过精准局麻药配（3mg/mL）未影响透明质酸的结构支撑力与动态美学效果，显著降低了注射疼痛感，为鼻唇沟等高敏区域提供了疼痛管理-美容效果-安全性三重优化的新型解决方案，具有显著临床转化价值。
关键词
参考
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