Genistein 对糖尿病心血管并发症作用机制的研究

李 娜, 潘 英, 赵 禹
深圳市宝安区中心医院 518102

摘要

目的：糖尿病是一种内分泌代谢紊乱引起的慢性疾病，已经发展成全球性公共健康问题。目前，全球糖尿病患者已达约 4.25 亿。据估计，到 2045年糖尿病发病率将增加 48%。糖尿病是终末期肾病、成人视力障碍及心血管疾病的主要原因。Genistein，一种天然的主要存在于大豆类的植物雌激素，在肿瘤、心血管疾病等多种疾病预防中具有十分重要的意义。既往研究表明，膳食补充植物雌激素可以预防动脉粥样硬化。本文主要通过阐述Genistein 对糖尿病心血管并发症作用的机制、现状，以期改善糖尿病合并心血管并发症患者的预后。

关键词

Genistein；糖尿病；心血管；发生机制

参考

[1].Ma, R., Epidemiology of diabetes and diabetic complications in China. Diabetologia, 2018. 61(6): p. 1249-1260. [2].Weng L, Zhang F, Wang R, et al. A review on protective role of genistein against oxidative stress in diabetes and related complications[J]. Chem Biol Interact, 2019,310:108665. [3].Chen C, Zheng H, Qi S. Genistein and Silicon Synergistically Protects Against Ovariectomy-Induced Bone Loss Through Upregulating OPG/RANKL Ratio[J]. Biol Trace Elem Res, 2019,188(2):441-450. [4].Lei X W, Li Q, Zhang J Z, et al. The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress[J]. Ophthalmic Res, 2019,62(2):80-92. [5].Li X, Ke X, Li Z, et al. Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation[J]. Biochem Biophys Res Commun, 2019,514(1):1-8. [6]. Liu M, Wang G, Xu R, et al. Soy Isoflavones Inhibit Both GPIb-IX Signaling and alphaIIbbeta3 Outside-In Signaling via 14-3-3zeta in Platelet[J]. Molecules, 2021,26(16). [7]. Cyr A R, Huckaby L V, Shiva S S, et al. Nitric Oxide and Endothelial Dysfunction[J]. Crit Care Clin, 2020,36(2):307-321. [8]. Amerizadeh A, Asgary S, Vaseghi G, et al. Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis[J]. Curr Probl Cardiol, 2021:100902.