系统免疫炎症指数对急性脑梗死患者溶栓后早期神经功能恶化的预测价值

杨 树琴, 陆 景红
安徽医科大学附属阜阳人民医院 安徽阜阳 236000

摘要

目的：探讨系统免疫指数（SII）对急性脑梗死患者溶栓后早期神经功能恶化的预测价值。方法：连续入选我院 2020 年 1 月至 2021 年 12 月行静脉溶栓治疗的急性缺血性脑卒中患者 297 例，按溶栓后 24 小时内 NIHSS 评分总分增加≥4 分、NIHSS 总分无变化、NIHSS 总分下降≥4 分或神经功能完全恢复，将其分为恶化组(n=47)，无变化组(n=116)及改善组(n=134)，根据血常规、血生化检测计算 SII，采用多因素有序 Logistic 回归分析和 ROC曲线评价 SII 对急性缺血性脑卒中患者溶栓后早期神经功能恶化的相关性及预测价值。结果：三组患者年龄、糖尿病发生率、空腹血糖、C 反应蛋白、高密度脂蛋白、PLR、NLR、SII 比较，差异有统计学意义（P＜0.05），多因素有序 Logistic 回归分析显示：年龄、C 反应蛋白、HDL-C、SII 是急性缺血性脑卒中患者溶栓后早期神经功能恶化的独立影响因素（P＜0.05）；ROC 曲线显示 SII 在预测溶栓后早期神经功能恶化时，其最佳临界值为 825.62，相应的灵敏度为 66.0％，特异度为 74.1％。结论：SII 是溶栓后短期神经功能恶化的独立危险因素，并具有一定的预测价值，可作为预测溶栓患者预后的有效指标。

关键词

急性缺血性脑卒中;静脉溶栓；系统免疫炎症指数(SII)

参考

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