羟氯喹诱发急性泛发性发疹性脓疱病的护理经验

王 晶1, 王 琴2, 卢 云2, 梁 江2
1.贵州中医药大学研究生院贵州贵阳550002；2.贵州中医药大学第一附属医院风湿血液科贵州贵阳550002

摘要

目的：为急性泛发性发疹性脓疱病患者的康复提供护理经验。结论急性泛发性发疹性脓疱病是一种严重的急性皮肤重症，通常由感染、药物诱发。我们通过对患者的详细诊治、护理过程、转归结局进行分析记录，得到宝贵的护理经验，为今后此类患者的护理提供参考。

关键词

急性泛发性发疹性脓疱病；羟氯喹；系统性红斑狼疮；护理

参考

[1].Meier-SchiesserB,FeldmeyerL,JankovicD,etal.CulpritDrugsInduceSpecificIL-36OverexpressioninAcuteGeneralizedExanthematousPustulosis.JInvestDermatol.2019Apr;139(4):848-858.[2].DeLuigiG,ZgraggenL,KottanattuL,etal.SkinandMucousMembraneEruptionsAssociatedwithChlamydophilaPneumoniaeRespiratoryInfections:LiteratureReview.Dermatology.2021;237(2):230-235.[3].GiancristoforoS,DiociaiutiA,MenisD,etal.AcutegeneralizedexanthematouspustulosisassociatedwithEpstein-Barrvirusinfectionreactivation.GItalDermatolVenereol.2019Feb;154(1):91-92.[4].HayashiE,ImanishiH,TateishiC,etal.AcutegeneralizedexanthematouspustulosisassociatedwithhumanparvovirusB19infectioninanadolescent.JDermatol.2021May;48(5):e236-e237.[5].DeA,DasS,SardaA,etal.AcuteGeneralisedExanthematousPustulosis:AnUpdate.IndianJDermatol.2018Jan-Feb;63(1):22-29.[6].DaCunhaM,MooreS,KaplanD.Cephalexin-inducedacutegeneralizedexanthematouspustulosis.DermatolReports.2018Oct1;10(2):7686.[7].KumarV,KalaiselvanV,KumarAP,etal.Cefixime-associatedacutegeneralizedexanthematouspustulosis:RarecasesinIndia.IndianJPharmacol.2018Jul-Aug;50(4):204-207.[8].Torres-NavarroI,Abril-PérezC,Roca-GinésJ,etal.Acaseofcefditoren-inducedacutegeneralizedexanthematouspustulosisduringCOVID-19pandemics.Severecutaneousadversereactionsareanissue.JEurAcadDermatolVenereol.2020Oct;34(10):e537-e539.[9].McDonaldKA,PierscianowskiTA.ACaseofAmoxicillin-InducedAcuteGeneralizedExanthematousPustulosisPresentingasSepticShock.JCutanMedSurg.2017Jul/Aug;21(4):351-355.[10]ColemanLemanI,RuizG,BrahmbhattS,etal.AcutegeneralizedexanthematouspustulosisandStevens-Johnsonsyndromeoverlapduetohydroxychloroquine:acasereport.JMedCaseRep.2020;14(1):210.[11]LitaiemN,HajlaouiK,KarrayM,etal.AcutegeneralizedexanthematouspustulosisafterCOVID-19treatmentwithhydroxychloroquine.DermatolTher.2020;33(4):e13565.[12]LeeJY,VinayagamoorhyN,HanK,etal.AssociationofPolymorphismsofCytochromeP4502D6WithBloodHydroxychloroquineLevelsinPatientsWithSystemicLupusErythematosus.ArthritisRheumatol.2016;68(1):184-90.