GnRHa治疗中枢性性早熟儿童疗效及安全性评价

李 婷1, 王兰 英2
1.华北理工大学；2.唐山市妇幼保健院

摘要

目的：青春期开始的时间对儿童的生理、心理和长期健康都有相当大的影响。中枢性性早熟是儿科内分泌系统的常见病之一，促性腺激素释放激素类似物作为国际上治疗中枢性性早熟的主要药物，其通过抑制下丘脑-垂体-性腺轴的活动和性激素分泌，进而减缓患儿骨龄进展、改善成年身高。本文结合了近些年促性腺激素释放激素类似物治疗中枢性性早熟患儿方面的研究，就其疗效及近远期安全性进行综述，以探讨并不断完善其效用及安全性相关证据。

关键词

促性腺激素释放激素类似物；中枢性性早熟；疗效；安全性

参考

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