巨噬细胞对免疫反应影响的研究进展

张 译中, 高 良辉
海南医学院第一附属医院

摘要

目的：得益于近年来基础科学的进展，巨噬细胞已经出现在免疫学和移植研究的前沿。近年来的研究发现了以前未确定的巨噬细胞种群，扩展了传统的巨噬细胞表型。越来越多的证据表明巨噬细胞在免疫反应中扮演着重要的角色。巨噬细胞可以启动适应性免疫反应，延续T细胞介导的排斥反应和抗体介导的排斥反应，并促进同种异体移植物纤维化。巨噬细胞通过何种方式加重或减轻免疫排斥反应，促进移植物存活一直是免疫学研究的热点。本文着重对巨噬细胞的极化、不同类型巨噬细胞在器官移植中的免疫作用进行论述。

关键词

巨噬细胞；免疫反应；器官移植；调节性T细胞

参考

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