FOXM1 在癌症中的表达及研究进展

徐 碧宇, 姬 艳琦, 常 粒园, 杨 晶玉, 宋 旭东
华北理工大学附属医院病理科 河北唐山 063000

摘要

目的：FOXM1 是一种广泛研究的转录因子，包含了大多数恶性肿瘤的特征。FOXM1 至少参与 12 种不同的癌症类型，是结肠、乳腺、卵巢、肝、胃等实体瘤中最常见的过表达基因之一。它也在其他癌症中异常表达，如急性髓性白血病、基底细胞癌等，其过表达对肿瘤的发生、发展和耐药具有重要意义。本文综述了近年来积累的大量文献，强调了 FoxM1 的关键特征，表明 FOXM1 基因可以作为不同癌症中的一种新的预测、预后和治疗标志物，对癌症发生发展机制及药物治疗预后提供理论依据。

关键词

关键词：FOXM1；癌症；结直肠癌

参考

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