APT在脑梗死影像诊断中的研究进展

张 福兰, 王 红, 郝 璐, 马 景旭
新疆医科大学第二附属医院医学影像中心 乌鲁木齐 830000

摘要

目的：脑梗死已经成为我国居民死亡的第一位病因[1]，该病不仅起病急，而且致死率、致残率高，近年来脑卒中新发病例逐年升高，且病因多变复杂，除自身因素外，还与生活方式、生态环境等有关。Moran等2010年也有研究发现[2]，我国的脑梗死患者近年来逐年增多，20年后脑梗死患者发病患病率升高二分之一。对于脑梗死患者来说，治疗关键把握时间窗，对不同发病时期的患者采取不同的治疗方式，这种方式可以提高临床的治疗效果，且对患者后期恢复至关重要[3]。酰胺质子转移成像技术(APT)作为分子磁共振成像技术，通过对组织中的内源性蛋白质及酰胺质子产生图像来显像。APT成像技术是化学交换饱和转移(CEST)成像技术的一种，目前已应用于蛋白质含量和酸碱度的测定，且酰胺质子的交换速率对pH值依赖性很强。下文主要对APT成像技术原理及其在脑梗死影像诊断中的研究进展简要综述。

关键词

APT；脑梗死；影像诊断；应用进展；临床应用

参考

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