首页出版说明中文期刊中文图书环宇英文官网付款页面

甲状腺术后恶心呕吐

李 静
华北理工大学 河北唐山 063000

摘要


摘要:目的:甲状腺PONV一直是困扰麻醉和外科手术的主要问题。严重和顽固的甲状腺PONV可显著延长病患住院时间,还有可能引起威胁病患生命安全的严重并发症[1-2],比如酸碱失衡、水电解质紊乱、切口出血过多及肿胀、反流误吸性肺炎等,造成病患预后不良。因此,对甲状腺PONV的防治方法日益受到人们的关注,应积极预防甲状腺PONV,减轻甲状腺病患术后不适感,降低造成患者预后不良的其他并发症的产生。PONV发生因素较多,发生机制尚未完全明确,没有单一的专用药物或一系列药物可完全抑制甲状腺PONV的发生,这可能是与它们不能阻滞对呕吐中枢的所有通路有关。但是,由于PONV发生机制中的多受体起源,联合治疗方式逐渐被广泛应用。针对甲状腺PONV高危群体,临床研究推荐多种作用机制不同的药物联合使用,其预防效果显著优于单一药物[3]。本文就对甲状腺PONV影响因素以及预防处理等相关问题进行阐述。

关键词


甲状腺PONV;盐酸戊乙奎醚;地塞米松;颈浅丛神经阻滞

全文:

PDF


参考


[1]AN TJ,MEYER T,APFEL CC,et al.Consensus guide-linesfor managing.postoperative.nausea.and.vomiting[J].Anesthnalg,2003,97(1):62-71.[2]马俊丽;魏新川.术后恶心呕吐病因、机制和治疗进展[J].实用医院临床杂志,2022,19(01):190-193.[3]宋阳;李洋;郑文慧;董有静.术后恶心呕吐防治措施的研究进展[J].实用药物与临床,2017,(06):720-724.[4]蔡丙华, 石磊.甲状腺疾病手术中甲状旁腺损伤的防治体会[J].右江民族医学院学报, 2011, 33 (3) :304-305.[5]阳瑾.甲状腺疾病外科手术治疗的临床分析[J].中国医学创新, 2013, 10 (17) :41-42.[6]DAFEO,COCHRANE E,BALASUBRAMANIAN S P.Reoperation for.bleeding.after.thyroid.and.parathyroid.surgery:incidence,riskfactors,prevention,and management[J].World JSurg,2020,44(4):1156-1162.[7]an.TJ.Postoperative.nausea.and.vomiting-can.it.be.eliminated?JAMA, 2002, 287 (10) :1233-1236.[8]陈明慧;俞红丽;常涛;傅舒昆;李会;林福清.右美托咪定用于预防腹腔镜胆囊切除术后恶心呕吐的效果[J].临床麻醉学杂志,2017,(03):261-263.[9]Ahmad R,Changeez M,Tameez UD,et al.Role of prophylactic dexamethasone before thyroidectomy in reducing postoperative pain,nausea and vomiting[J].Cureus,2019;11(5):e4735.[10]魏世雄.甲状腺切除术后恶心呕吐发生现状及影响因素[J].医学理论与实践,2021,(18):3185-3186.[11]马俊丽;魏新川.术后恶心呕吐病因、机制和治疗进展[J].实用医院临床杂志,2022,19(01):190-193.[12]Zhong W,Shahbaz O,Teskey G,et al.Mechanisms of nausea and vomiting:current knowledge and recent advances in intracellular emetic signaling systems[J].Int J Mol Sci,2021,22 (11):5797-5830.[13]卢薪竹;苏帆.术后恶心呕吐的中西医防治研究进展[J].中国中医药现代远程教育,2022,20(14):203-205.[14]TROPE A,RAEDER JC.Can postoperative nausea and vomitingbe predieted[J].Anesth,2000,120(20):2423-2426.[15]Apfel CC,Heidrich FM,Jukar-Rao S,Jalota L,Hornuss C,Whelan RP,Zhang K,Cakmakkaya OS.Evidence-based analysis of risk factors for postoperative nauseaand vomiting.Br J Anaesth 2012;109:742-753.[16]Gan TJ,Belani KG,Bergese S,Chung F,Diemunsch P,Habib AS,Jin Z,Kovac AL,Meyer TA,Urman RD,Apfel CC,Ayad S,Beagley L,Candiotti K,Englesakis M,Hedrick TL,Kranke P,Lee S,Lipman D,Minkowitz HS,Morton J,Philip BK.Fourth consensus guidelines for the management of postoperative nausea andvomiting.Anesth Analg 2020;131:411-448.[17]曹亚;喻君;郭文俊;戴泽平.术前焦虑对妇科腔镜患者术后恶心呕吐的影响[J].皖南医学院学报,2020,39(04):365-367.[18]STAMENKOVIC.DM,RANCIC.NK,LATAS.MB,etal.Preoperativ综述249医学研究e anxiety and implications on postoperative recovery:what can we do to change our history [J].Minerva Anestesiologica,2018,84(11):1307-1317.[19]赵诚, 房世保, 刘岩, 等.颈过伸体位引起椎动脉血流动力学变化与甲状腺术后恶心呕吐综合征相关性分析.中国超声医学杂志, 2010, 26 (7) :606-608.[20]Elliott RA,Payne K,Moore JK,et al.Clinical and economic choices in anaesthesia for day surgery:a prospective randomised controlled trial[J].Anaesthesia,2003;58(5):412-21.[21]Gan TJ,Belani KG,Bergese S,et al.Fourth consensus guidelines for the management of postoperative nausea and vomiting[J].Anesthes Analges,2020;131(2):411-48.[22]Apfel CC, Meyer A, Orhan-Sungur M, et al.Supplemental intravenous crystalloids for the prevention of postoperative nausea and vomiting:quantitative review.Br J Anaesth, 2012, 108 (6) :893-902.[23]侯瑞雪,尹橙,王天龙.全身麻醉或联合颈丛阻滞用于甲状腺手术术后镇痛效果的观察[J].首都医科大学学报,2020,41(2):253-256.[24]朱炜,杨许丽,崔士和,等.静脉全麻复合双侧颈丛浅神经阻滞对老年甲状腺手术患者术后恶心呕吐的影响[J].实用老年医学,2016,39(12):997-999.[25]Stadler M,Bardiau F,Seidel L,et al.Difference in Risk Factors for PostoperativeNausea and Vomiting[J].Anesthesiology,2003,98(1):46-52[26]Watcha MF and Smith I.Cost-effectiveness analysis of anti-emetic Therapy for ambulatory surgery.J Anaesth 2000;85:675-677.[27]Apfel CC, Meyer A, Orhan-Sungur M, et al.Supplemental intravenous crystalloids for the prevention of postoperative nausea and vomiting:quantitative review.Br J Anaesth, 2012, 108 (6) :893-902.[28]HAN X Y,LIU H,LIU C H,et al. Synthesis of the optical isomers of a new anticholinergic drug,penehyclidine hydrochloride(8018)[J]. Bioorg Med Chem Lett,2005,15(8):1979-1982[29]李荣荣;董洪权;刘存明;丁正年;陈静.盐酸戊乙奎醚预防甲状腺 术 后恶 心呕 吐 的效 果观 察[J].南 京 医科 大学 学 报(自 然 科学版),2021,(04):609-611.[30]Henzi I, Sonderegger J, Tramer MR. Efficacy, doseresponse, and adverse effects otdroperidol for prevention of postoperative nausea and vomiting. Can J Anesth 200047(6): 537-551[31]Lee Y, Wang PK,Lai HY,et al. Haloperdol is as effective as ondansetron forpreventing post operative nausea and vomiting. Can J Anesth. 2007; 54(5): 349-354[32]嵇晓阳,瞿慧,鲁刚,等.甲强龙联合格拉司琼预防乳房肿块切除术后恶心呕吐[J].临床麻醉学杂志,2015,31(12):1196-1198[33]KURYSHEV Y A,BROWN A M,WANG L,et al. Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels[J]. J Pharmacol Exp Ther,2000,295(2):614-620[34]Bidwai AV, Meuleman T, Phatte wp. Prevention of postoperative nausea with dimenhydrinate (Dramamine) and droperidol (Inapsine) J Anesth Clin Pharmacology2007;23(4): 341-356[35]Grape S,Usmanova I,Kirkham K,et al.Intravenous dexamethasone for prophylaxis of postoperative nausea and vomiting after administration of long-acting neuraxial opioids:a systematic review and meta-analysis[J].Anaesthesia,2018,73(4):480-489.[36]Lee M,Lee K,Kim H,et al.Comparison of ramosetron plus dexamethasone.with.ramosetron.alone.on.postoperative.nausea,vomiting,shivering and pain after thyroid surgery[J].The Korean journal of pain,2015,28(1):39-44.[37]杜静;王善秋.颈浅神经丛阻滞预防甲状腺术后恶心呕吐研究进展[J].现代医药卫生,2020,(08):1174-1176.[38]KLEIN SM,GREENGRASS RA,KNUDSEN N,et al.Regional anesthesia for thyroidectomy in two patients with amiodarone-induced hyperthyroidism[J].Anesth Analg,1997,85(1):222-224.[39]肖春龙;张应平.超声引导定位与传统解剖定位行臂丛联合颈丛神经阻滞的麻醉效果对比[J].临床医学研究与实践,2016,(21):46-47.[40]邱宇飞;王建刚;岳隆基;朱健.经皮穴位电刺激联合托烷司琼、地塞米松预防日间甲状腺切除术后恶心呕吐 40 例[J].安徽医药,2021,(11):2277-2281[41]肖媛;张学忠;耿英杰;席宏杰;李爱民;董弘;刘晶;邢喜春;杨万超.双侧内关穴、合谷穴经皮穴位电刺激预防甲状腺切除术后恶心呕吐的效果[J].临床麻醉学杂志,2021,(06):588-591.[42]吴征元;杜佳溪;刘尧;申文.术后恶心呕吐的风险因素及防治措施进展[J].中国医药导报,2019,16(12):38-41.[43]Wiesmann T, Kranke P, Eberhart L.Postoperative nausea and vomiting-a narrative review of pathophysiology, pharmacotherapy and clinical management strategies[J].Expert Opin Pharmaco, 2015, 16 (7) :1069-1077.




DOI: http://dx.doi.org/10.12361/2661-3603-05-14-141060

Refbacks

  • 当前没有refback。