PQSM 在神经退行性疾病中的应用进展

侯 鹏飞, 韩 雪, 王 红*
新疆医科大学第二附属医院影像中心 乌鲁木齐 830063

摘要

摘要：神经退行性疾病(neurodegenerative disease)是神经元结构及功能进行性丧失为主要特点的异质性疾病，包括阿尔茨海默病(Alzheimer's
disease， AD)、帕金森病(Parkinson's disease，PD)、肌萎缩侧索硬化症 (Amyotrophic lateral sclerosis，ALS)、亨廷顿病（Huntington's disease，
HD）、额颞叶痴呆(Frontotemporal dementia，FTD) 、威尔逊病（Wilson's disease，WD）。定量磁敏感成像（Quantitative susceptibility mapping，
QSM）成像是近年来发展起来的磁共振成像技术，通过测量脑内组织铁含量，反映组织细胞的生理及病理信息。本文旨在阐述 QSM 技术优
势，综述其在神经退行性相关疾病中的研究现状。

关键词

关键词：定量磁敏感成像、神经退行性疾病

参考

[1]Sun, Y., et al., Mechanisms of Ferroptosis and Emerging Links to

the Pathology of Neurodegenerative Diseases. Front Aging Neurosci,

2022. 14: p. 904152.

[2]Haller, S., et al., Susceptibility-weighted Imaging: Technical

Essentials and Clinical Neurologic Applications. Radiology, 2021.

299(1): p. 3-26.

[3]杨奡偲, 阿尔兹海默症患者全脑铁沉积与脑结构改变的 MRI

研究, 2021, 山东大学. 第 71 页.

[4]Hwang, E.J., et al., Texture analyses of quantitative susceptibility

maps to differentiate Alzheimer's disease from cognitive normal and

mild cognitive impairment. Med Phys, 2016. 43(8): p. 4718.

[5]Du L, et al., Increased Iron Deposition on Brain Quantitative

Susceptibility Mapping Correlates with Decreased Cognitive Function

in Alzheimer's Disease. ACS Chem Neurosci, 2018. 9(7): p. 1849-1857.

[6]van Bergen, J.M., et al., Colocalization of cerebral iron with

Amyloid beta in Mild Cognitive Impairment. Sci Rep, 2016. 6: p. 35514.

[7]Tiepolt, S., et al., Quantitative Susceptibility Mapping of

Amyloid-beta Aggregates in Alzheimer's Disease with 7T MR. J

Alzheimers Dis, 2018. 64(2): p. 393-404.

[8]Murakami, Y., et al., Usefulness of quantitative susceptibility

mapping for the diagnosis of Parkinson disease. AJNR Am J

Neuroradiol, 2015. 36(6): p. 1102-8.

[9]Du G, et al., Quantitative susceptibility mapping of the midbrain

in Parkinson's disease. Mov Disord, 2016. 31(3): p. 317-24.

[10]Uchida, Y., et al., Magnetic Susceptibility Associates With

Dopaminergic Deficits and Cognition in Parkinson's Disease. Mov

Disord, 2020. 35(8): p. 1396-1405.

[11]Nikparast, F., Z. Ganji and H. Zare, Early differentiation of

neurodegenerative diseases using the novel QSM technique: what is the

biomarker of each disorder? BMC Neurosci, 2022. 23(1): p. 48.

[12]He, N., et al., Dentate nucleus iron deposition is a potential

biomarker for tremor-dominant Parkinson's disease. NMR Biomed,

2017. 30(4).

[13]Eskreis-Winkler, S., et al., The clinical utility of QSM: disease

diagnosis, medical management, and surgical planning. NMR Biomed,

2017. 30(4).

[14]Acosta-Cabronero, J., et al., Quantitative Susceptibility MRI to

Detect Brain Iron in Amyotrophic Lateral Sclerosis. Radiology, 2018.

289(1): p. 195-203.

[15]Schweitzer, A.D., et al., Quantitative susceptibility mapping of

the motor cortex in amyotrophic lateral sclerosis and primary lateral

sclerosis. AJR Am J Roentgenol, 2015. 204(5): p. 1086-92.

[16]van Bergen, J.M., et al., Quantitative Susceptibility Mapping

Suggests Altered Brain Iron in Premanifest Huntington Disease. AJNR

Am J Neuroradiol, 2016. 37(5): p. 789-96.

[17]Chen, L., et al., Altered brain iron content and deposition rate in

Huntington's disease as indicated by quantitative susceptibility MRI. J

Neurosci Res, 2019. 97(4): p. 467-479.

[18]van Bergen, J.M., et al., Quantitative Susceptibility Mapping

Suggests Altered Brain Iron in Premanifest Huntington Disease. AJNR

Am J Neuroradiol, 2016. 37(5): p. 789-96.

[19]Sheelakumari, R., et al., Assessment of Iron Deposition in the

Brain in Frontotemporal Dementia and Its Correlation with Behavioral

Traits. AJNR Am J Neuroradiol, 2017. 38(10): p. 1953-1958.

[20]刘海燕与赵超蓉, 血管性痴呆的中西医研究进展. 现代中

西医结合杂志, 2021. 30(03): 第 334-338 页.

[21]Fritzsch, D., et al., Seven-tesla magnetic resonance imaging in

Wilson disease using quantitative susceptibility mapping for

measurement of copper accumulation. Invest Radiol, 2014. 49(5): p.

299-306.

[22]Doganay, S., et al., Magnetic Susceptibility Changes in the Basal

Ganglia and Brain Stem of Patients with Wilson's Disease: Evaluation

with Quantitative Susceptibility Mapping. Magn Reson Med Sci, 2018.

17(1): p. 73-79.

通讯作者：王红，女性，硕士，副教授，研究方向：中枢神经

系统 ，E-mail：[e-mail]

基金项目：2019，新疆医科大学第二附属医院，磁共振 NODDI

技术对帕金森患者黑质纹状体病变的临床应用研究，2019DO1C227