急性脑梗死静脉溶栓治疗预后的研究进展

李 媛1, 东晶 晶1, 李永 秋2
1.华北理工大学 2.唐山市工人医院

摘要

摘要：目的：急性缺血性卒中(Acute Ischemic Stroke,AIS)患者在症状出现后 4.5 小时内给予阿替普酶静脉溶栓(Intravenous Thrombolysis,IVT)仍然是唯一
被批准的脑再灌注治疗，能够明显恢复血流，改善神经预后。尽管组织纤溶酶原激活剂(Recombinant Tissue Type Plasminogen Activator,rt-PA)被证
实在逆转神经功能缺损和改善临床结果方面有效，然而，大量患者在接受溶栓治疗后，早期神经功能并未得到有效改善，部分患者在治疗 90
天后预后较差，形势不容乐观。这部分患者往往给家庭和社会带来越来越大的负担。所以对静脉溶栓患者进行早期的评估，尽早的对危险因素
进行二级干预，改善患者的预后和生存质量是目前最需要解决的问题。通过研究急性脑梗死静脉溶栓治疗后的预后及影响因素，提高溶栓的有
效性，改善患者的生存质量，减轻家庭和社会的负担。

关键词

关键词：急性脑梗死；静脉溶栓；预后；影响因素

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作者简介：姓名：李媛 性别：女 学历：硕士 研究方向：

脑血管病 籍贯：河北省唐山市

通讯作者：姓名：李永秋 性别：男 学历：博士 研究方向：

脑血管病 认知障碍 籍贯：河北省唐山市 主任医师 硕士生导师