NPAR、MPVLR 与急性缺血性脑卒中静脉溶栓后预后相关性的研究进展

薛 院院, 张 晓希, 王 博瑶
华北理工大学附属医院 河北唐山 063000

摘要

摘要：目的：急性缺血性脑卒中(AIS)具有高发病率、高致残率、高复发率、以及多并发症的特点，耗费大量人力、物力，财力。早期评估及治疗急性
缺血性脑卒中对提高患者生存率和改善预后尤为重要。急性脑梗死发生后，同时激活外周免疫和中枢免疫系统，引起外周中性粒细胞、淋巴细
胞等向中枢募集，在抗炎过程均有白蛋白参与，血小板在缺血性脑卒中发病机制中扮演着重要角色。本文主要综述中性粒细胞百分数与白蛋白
比值（NPAR）、平均血小板体积与淋巴细胞比值（MPVLR）与缺血性脑卒中静脉溶栓后预后相关性的研究进展进行综述。

关键词

关键词：急性缺血性脑卒中；中性粒细胞百分比与白蛋白比值；平均血小板体积与淋巴细胞比值；炎症；预后；

参考

[1]. WenJun T,LongDe W. China stroke surveillance report 2021.[J].

Military Medical Research,2023,10(1).

[2]. L. Catanese, J. Tarsia, M. Fisher, Acute ischemic stroke therapy

overview, Circ. Res. 120 (3) (2017) 541–558.

[3]. Y. Mo, Y.Y. Sun, K.Y. Liu, Autophagy and inflammation in

ischemic stroke, Neural Regen Res 15 (8) (2020) 1388–1396.

[4]. L D A,Mario N D,Kunal B, et al. Neuroinflammation in Acute

Ischemic and Hemorrhagic Stroke.[J]. Current neurology and

neuroscience reports,2023,23(8).

[5]. Yang C, Hawkins KE, Dore S, Candelario-Jalil E.

Neuroinflammatory mechanisms of blood-brain barrier damage in

ischemic stroke. Am J Physiol Cell Physiol. 2019;316(2):C135–C53.

[6]. Yildirim T, Okutan O, Akpinar E, Yilmaz A, Isik

HS.Neuroprotective effects of high-dose human albumin against

trau-matic spinal cord injury in rats. Bratisl Lek Listy.

2018;119(2):86–91.

[7]. Dehao Y,Honghao H,Yiyun W, et al. Dynamic Decrease in

Eosinophil After Intravenous Thrombolysis Predicts Poor Prognosis of

Acute Ischemic Stroke: A Longitudinal Study [J]. Frontiers in

Immunology,2021,12.

[8]. Ya L,Yanhan L,Juanqing Y, et al. The neutrophil

percentage-to-albumin ratio is associated with all-cause mortality in

critically ill patients with acute myocardial infarction.[J]. BMC

cardiovascular disorders,2022,22(1).

[9]. ChienAn K,KuHao F,MingShao T, et al. Prognostic Value of

Neutrophil Percentage-to-Albumin Ratio in Patients with Oral Cavity

Cancer[J]. Cancers,2022,14(19).

[10]. Ting C,Changyi W,Qiange Z, et al. Association between

neutrophil percentage-to-albumin ratio and 3-month functional outcome

in acute ischemic stroke patients with reperfusion therapy [J]. Frontiers in

Neurology,2022,13.

[11]. Zhang H, Wu T, Tian X, Lyu P, Wang J, Cao Y. High

Neutrophil Percentage-To-Albumin Ratio Can Predict Occurrence of

Stroke-Associated Infection. Front Neurol. (2021) 12:705790.

[12]. XinNi L,YiQing S,ZuoQiao L, et al. Neutrophil percentage to

albumin ratio is associated with stroke-associated pneumonia and poor

outcome in patients with spontaneous intracerebral hemorrhage.[J].

Frontiers in immunology,2023,14.

[13]. Ornek E, Kurtul A. Relationship of mean platelet volume to

lymphocyte ratio and coronary collateral circulation in patients with

stable angina pectoris. Coron Artery Dis. 2017;28:492–7.

[14]. Kurtul A, Acikgoz SK. Usefulness of mean platelet

volume-to-lymphocyte ratio for predicting angiographic no-reflow and

short-term prognosis after primary percutaneous coronary intervention in

patients with ST-segment elevation myocardial infarction. Am J Cardiol.

2017;120:534–41.

[15]. Fan W,Qian W,Yingli Q, et al. A new marker of short-term

mortality and poor outcome in patients with acute ischemic stroke: Mean

platelet volume-to-lymphocyte ratio[J]. Medicine,2022,101(40).