艾司氯胺酮在老年患者麻醉中的研究进展

张淑 芳1, 王 英2, 王东 梅1, 齐贺 斌1
1.华北理工大学 2.唐山市工人医院

摘要

摘要：目的：艾司氯胺酮是一种通过与谷氨酸 N-甲基-D-天冬氨酸(NMDA)受体、阿片受体、M 胆碱受体、单胺受体、腺苷受体和其他嘌呤受体相互作
用从而发挥镇痛、镇静、抗炎、抗抑郁作用。老年人生理条件较特殊且多合并有基础疾病，如何做好老年患者的麻醉，一直是麻醉医生比较关
心的问题。 艾司氯胺酮作为唯一具有镇痛作用的静脉麻醉药且对呼吸循环影响较小的药理特点使其在老年患者麻醉中显示出独特的优势作用，
已经越来越多地被应用于老年患者麻醉管理。现在就艾司氯胺酮在老年人临床麻醉中的应用予以综述，从而使艾司氯胺酮可以更好地应用于老
年患者麻醉工作中。

关键词

关键词：老年；艾司氯胺酮；全醉；临床应用

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作者简介:姓名:张淑芳 性别:女 学历:硕士 研究方向:老年

麻醉 籍贯:河北省唐山市

通讯作者:姓名:王英 性别:女 学历:博士 研究方向:术后谵

妄 老年麻醉 籍贯:河北省唐山市 主任医师 硕士生导师