circRNA在甲状腺癌中的研究进展

鲁桂 艳1, 刘阁 玲2
1.华北理工大学 ；2.唐山市工人医院内分泌一科 河北唐山 063000

摘要

摘要：目的：甲状腺癌(thyroidcancer，TC)是一种起源于甲状腺滤泡上皮或滤泡旁上皮细胞的恶性肿瘤，它的生存率明显高于其他类型的癌症，这主要取决于TC的具体类型和分期。近年来，TC在全球范围内的发病率逐年上升。但迄今为止，其发病机制仍不清楚。环状RNA（circularRNA，circRNA）是一类新型的长链非编码RNA（longnon-codingRNA，lncRNA），具有闭环结构，在TC中可以调控基因的表达。此外，circRNA的生物学功能还包括充当miRNA海绵、与蛋白质相互作用以及作为翻译模板。基于以上特征，它被认为是多种疾病的功能性生物标志物和治疗靶点。在这篇综述中，我们总结了circRNA的生物学功能，并讨论了它在TC中潜在临床意义。

关键词

关键词：甲状腺癌；环状RNA；功能；生物标志物

参考

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