干细胞疗法及组织工程在血友病关节炎治疗中的研究进展

徐菊 菊1, 闫振 宇1
1.华北理工大学；2. 华北理工大学附属医院

摘要

摘要：血友病关节炎(HA)是血友病最常见的并发症之一，临床和亚临床状态频发出现关节出血，最终会导致不可逆转的损伤，是一种致残性疾病。现阶段最主要的医学手段是控制出血和手术治疗，这两种方式可短暂减轻关节炎的症状，但无法延缓病情进展。近年来，干细胞再生疗法已成为治疗血友病关节炎新疗法的核心，以骨髓间充质干细胞(MSC)尤为显著，为患者提供了高质量生活的希望。这篇综述主要以骨髓间充质干细胞疗法及组织工程技术治疗血友病关节炎2个方面进行表述。

关键词

关键词：干细胞；骨髓间充质干细胞；细胞治疗；关节炎；血友病；细胞支架；组织工程；

参考

[1]GUALTIEROTTI R, SOLIMENO L P, PEYVANDI F. Hemophilicarthropathy: Current knowledge and future perspectives [J]. J ThrombHaemost, 2021, 19(9): 2112-21.[2]HAUW W W S, CHIA J S J, NANDURKAR H H, et al. Thepotential role of protease systems in hemophilic arthropathy [J]. Bloodadvances, 2022, 6(18): 5505-15.[3]LYONS L P, WEINBERG J B, WITTSTEIN J R, et al. Blood inthe joint: effects of hemarthrosis on meniscus health and repairtechniques [J]. Osteoarthritis and cartilage, 2021, 29(4): 471-9.[4]HAN Z, ZHENG L, LUO D, et al. Ferroptosis: a new target foriron overload-induced hemophilic arthropathy synovitis [J]. Annals ofhematology, 2023, 102(5): 1229-37.[5]康坤龙, 王新涛. 生物支架材料促进骨髓间充质干细胞成骨分化的研究热点 %J 中国组织工程研究 [J]. 2022, 26(04): 597-603.[6]ZHANG H, CAI Q, ZHU Y, et al. A simple hydrogel scaffold withinjectability, adhesivity and osteogenic activity for bone regeneration [J].Biomater Sci, 2021, 9(3): 960-72.[7]WANG H. A Review of the Effects of Collagen Treatment inClinical Studies [J]. 2021, 13(22): 3868.[8]MUNIR N, CALLANAN A. Novel phase separatedpolycaprolactone/collagen scaffolds for cartilage tissue engineering [J].Biomed Mater, 2018, 13(5): 051001.[9]TAMADDON M, BURROWS M, FERREIRA S A, et al.Monomeric, porous type II collagen scaffolds promote chondrogenicdifferentiation of human bone marrow mesenchymal stem cells in vitro [J].Scientific reports, 2017, 7: 43519.[10]ELIMELECH R, KHOURY N, TAMARI T, et al. Use oftransforming growth factor-beta loaded onto beta-tricalcium phosphatescaffold in a bone regeneration rat calvaria model [J]. Clin Implant DentRelat Res, 2019, 21(4): 593-601.[11]LIU A, WANG P, ZHANG J, et al. Restoration Effect andTribological Behavior of Hyaluronic Acid Reinforced with GrapheneOxide in Osteoarthritis [J]. J Nanosci Nanotechnol, 2019, 19(1): 91-7.[12]OLATE-MOYA F, ARENS L, WILHELM M, et al.Chondroinductive Alginate-Based Hydrogels Having Graphene Oxide for3D Printed Scaffold Fabrication [J]. ACS Appl Mater Interfaces, 2020,12(4): 4343-57.[13]MAI Z, CHEN H, YE Y, et al. Translational and ClinicalApplications of Dental Stem Cell-Derived Exosomes [J]. Front Genet,2021, 12: 750990.