贝伐珠单抗治疗复发高级别胶质瘤的研究进展

靳 云泽
河北医科大学

摘要

摘要：高级别胶质瘤是一种恶性程度高、易复发、预后差的中枢神经系统恶性肿瘤，而手术合并术后Ｓｔｕｐｐ方案的治疗效果却并不能令人满意。以血管内皮生长因子为靶点的贝伐珠单抗具有抑制血管生长的功能，己经被美国食品药品监督管理局（ＦＤＡ）批准用于高级别胶质瘤的治疗。近年来，开展了许多有关贝伐珠单抗联合其他治疗手段治疗高级别胶质瘤的临床研究，但对于联合用药的疗效、模式及安全性尚存有较多争议。本文现就贝伐珠单抗的作用机制及贝伐珠单抗单药与联合化疗或其他药物在高级别脑胶质瘤中的应用进展进行综述，以期为临床上使用贝伐珠单抗治疗高级别胶质瘤提供参考。

关键词

关键词：高级别胶质瘤；贝伐珠单抗；复发；治疗；安全性

参考

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