TNF抑制剂对类风湿关节炎FLS的作用机制研究

尹 璐¹, 周 云涛¹, 张 晓阳¹, 田 卫²
1、华北理工大学
2、通讯作者华北理工大学

摘要

摘要：类风湿关节炎（rheumatoid arthritis，RA）是一种自身免疫性疾病，以滑膜炎症为主要表现。成纤维细胞样滑膜细胞(fibroblast-like-synoviocytes，FLS)已被证明在RA中有着重要作用。TNF抑制剂在RA治疗中的应用越来越广泛，但是治疗效果却因人而异，TNF抑制剂已被证明作用于RAFLS，但是其作用机制尚未明确，本研究将TNF抑制剂对RAFLS的作用机制做一综述，可以为TNF抑制剂的研发提供新的思路。

关键词

关键词：类风湿关节炎；成纤维样滑膜细胞；肿瘤坏死因子抑制剂

参考

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