精油作为皮肤渗透促进剂及其作用机制的预测

施 利群¹, 徐 建峰², 左 伟平², 张 利华², 倪 斌斌², 朗 古特²
1、通讯作者浙江鼎泰药业股份有限公司 浙江 314500
2、浙江鼎泰药业股份有限公司 浙江 314500

摘要

摘要：透皮给药系统是活性分子通过皮肤给药的给药途径。具有肝脏首过效应小、血浆药物浓度恒定、安全等优点。皮肤对药物和有毒分子的通过具有屏障功能，因此，渗透促进剂/增强剂用于增加药物通过皮肤的渗透性。在这篇综述中，回顾了可用于增加透皮应用中皮肤渗透性的精油的最新研究及其可能的作用机制。精油通过与角质层(SC)相互作用来增加皮肤渗透性。人们发现它们成功地增加了亲脂性和亲水性药物的皮肤渗透性。而且精油具有挥发性，不会在体内蓄积，很容易通过粪便和尿液排出体外

关键词

关键词：透皮给药系统；精油；皮肤促渗剂；作用机制

参考

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